Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3
- Авторы: Varlamova N.1, Churin A.2, Fomina T.2, Ermolaeva L.2, Vetoshkina T.2, Dubskaya T.2, Lamzina T.2, Fedorova E.2, Neupokoeva O.2, Skuridin V.1, Nesterov E.1, Larionova L.1, Chernov V.1,3
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Учреждения:
- Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
- Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
- Laboratory for Radionuclide Methods of Study, Tomsk Research Institute of Oncology
- Выпуск: Том 161, № 3 (2016)
- Страницы: 371-373
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237426
- DOI: https://doi.org/10.1007/s10517-016-3416-0
- ID: 237426
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Аннотация
We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.
Об авторах
N. Varlamova
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Автор, ответственный за переписку.
Email: varlamova@tpu.ru
Россия, Tomsk
A. Churin
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Россия, Tomsk
T. Fomina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Россия, Tomsk
L. Ermolaeva
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Россия, Tomsk
T. Vetoshkina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Россия, Tomsk
T. Dubskaya
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Россия, Tomsk
T. Lamzina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Россия, Tomsk
E. Fedorova
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Россия, Tomsk
O. Neupokoeva
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Россия, Tomsk
V. Skuridin
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
Россия, Tomsk
E. Nesterov
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
Россия, Tomsk
L. Larionova
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
Россия, Tomsk
V. Chernov
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University; Laboratory for Radionuclide Methods of Study, Tomsk Research Institute of Oncology
Email: varlamova@tpu.ru
Россия, Tomsk; Tomsk