Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3
- 作者: Varlamova N.1, Churin A.2, Fomina T.2, Ermolaeva L.2, Vetoshkina T.2, Dubskaya T.2, Lamzina T.2, Fedorova E.2, Neupokoeva O.2, Skuridin V.1, Nesterov E.1, Larionova L.1, Chernov V.1,3
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隶属关系:
- Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
- Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
- Laboratory for Radionuclide Methods of Study, Tomsk Research Institute of Oncology
- 期: 卷 161, 编号 3 (2016)
- 页面: 371-373
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237426
- DOI: https://doi.org/10.1007/s10517-016-3416-0
- ID: 237426
如何引用文章
详细
We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.
作者简介
N. Varlamova
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
编辑信件的主要联系方式.
Email: varlamova@tpu.ru
俄罗斯联邦, Tomsk
A. Churin
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
俄罗斯联邦, Tomsk
T. Fomina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
俄罗斯联邦, Tomsk
L. Ermolaeva
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
俄罗斯联邦, Tomsk
T. Vetoshkina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
俄罗斯联邦, Tomsk
T. Dubskaya
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
俄罗斯联邦, Tomsk
T. Lamzina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
俄罗斯联邦, Tomsk
E. Fedorova
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
俄罗斯联邦, Tomsk
O. Neupokoeva
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
俄罗斯联邦, Tomsk
V. Skuridin
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
俄罗斯联邦, Tomsk
E. Nesterov
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
俄罗斯联邦, Tomsk
L. Larionova
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
俄罗斯联邦, Tomsk
V. Chernov
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University; Laboratory for Radionuclide Methods of Study, Tomsk Research Institute of Oncology
Email: varlamova@tpu.ru
俄罗斯联邦, Tomsk; Tomsk
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