Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3
- Autores: Varlamova N.1, Churin A.2, Fomina T.2, Ermolaeva L.2, Vetoshkina T.2, Dubskaya T.2, Lamzina T.2, Fedorova E.2, Neupokoeva O.2, Skuridin V.1, Nesterov E.1, Larionova L.1, Chernov V.1,3
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Afiliações:
- Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
- Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
- Laboratory for Radionuclide Methods of Study, Tomsk Research Institute of Oncology
- Edição: Volume 161, Nº 3 (2016)
- Páginas: 371-373
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237426
- DOI: https://doi.org/10.1007/s10517-016-3416-0
- ID: 237426
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Resumo
We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.
Sobre autores
N. Varlamova
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Autor responsável pela correspondência
Email: varlamova@tpu.ru
Rússia, Tomsk
A. Churin
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Rússia, Tomsk
T. Fomina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Rússia, Tomsk
L. Ermolaeva
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Rússia, Tomsk
T. Vetoshkina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Rússia, Tomsk
T. Dubskaya
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Rússia, Tomsk
T. Lamzina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Rússia, Tomsk
E. Fedorova
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Rússia, Tomsk
O. Neupokoeva
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Rússia, Tomsk
V. Skuridin
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
Rússia, Tomsk
E. Nesterov
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
Rússia, Tomsk
L. Larionova
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
Rússia, Tomsk
V. Chernov
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University; Laboratory for Radionuclide Methods of Study, Tomsk Research Institute of Oncology
Email: varlamova@tpu.ru
Rússia, Tomsk; Tomsk