Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3
- Авторлар: Varlamova N.1, Churin A.2, Fomina T.2, Ermolaeva L.2, Vetoshkina T.2, Dubskaya T.2, Lamzina T.2, Fedorova E.2, Neupokoeva O.2, Skuridin V.1, Nesterov E.1, Larionova L.1, Chernov V.1,3
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Мекемелер:
- Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
- Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
- Laboratory for Radionuclide Methods of Study, Tomsk Research Institute of Oncology
- Шығарылым: Том 161, № 3 (2016)
- Беттер: 371-373
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237426
- DOI: https://doi.org/10.1007/s10517-016-3416-0
- ID: 237426
Дәйексөз келтіру
Аннотация
We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.
Авторлар туралы
N. Varlamova
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Хат алмасуға жауапты Автор.
Email: varlamova@tpu.ru
Ресей, Tomsk
A. Churin
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Ресей, Tomsk
T. Fomina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Ресей, Tomsk
L. Ermolaeva
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Ресей, Tomsk
T. Vetoshkina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Ресей, Tomsk
T. Dubskaya
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Ресей, Tomsk
T. Lamzina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Ресей, Tomsk
E. Fedorova
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Ресей, Tomsk
O. Neupokoeva
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Ресей, Tomsk
V. Skuridin
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
Ресей, Tomsk
E. Nesterov
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
Ресей, Tomsk
L. Larionova
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
Ресей, Tomsk
V. Chernov
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University; Laboratory for Radionuclide Methods of Study, Tomsk Research Institute of Oncology
Email: varlamova@tpu.ru
Ресей, Tomsk; Tomsk
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