Email this article Antihypoxic and Neuroprotective Effects of Glial Cell-Derived Neurotrophic Factor (GDNF) in Cultures of Dissociated Hippocampal Cells under Conditions of Experimental Hypoxia
- Authors: Vedunova M.V.1,2, Shishkina T.V.1,2, Mishchenko T.A.1,2, Mitroshina E.V.1,2, Astrakhanova T.A.1, Pimashkin A.S.1, Mukhina I.V.1,2
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Affiliations:
- N. I. Lobachevsky Nizhny Novgorod State University
- Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
- Issue: Vol 161, No 1 (2016)
- Pages: 168-174
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237237
- DOI: https://doi.org/10.1007/s10517-016-3369-3
- ID: 237237
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Abstract
We analyzed the effect of glial cell derived neurotrophic factor (GDNF) on changes in functional bioelectric and calcium activity in dissociated hippocampal cell cultures under conditions of modeled acute normobaric hypoxia in vitro. GDNF (1 ng/ml) partially neutralized the negative effects of hypoxia on cell survival and parameters of functional network activity. GDNF exhibited a pronounced anti-hypoxic effect.
About the authors
M. V. Vedunova
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Author for correspondence.
Email: mvedunova@yandex.ru
Russian Federation, Nizhny Novgorod; Nizhny Novgorod
T. V. Shishkina
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
Russian Federation, Nizhny Novgorod; Nizhny Novgorod
T. A. Mishchenko
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
Russian Federation, Nizhny Novgorod; Nizhny Novgorod
E. V. Mitroshina
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
Russian Federation, Nizhny Novgorod; Nizhny Novgorod
T. A. Astrakhanova
N. I. Lobachevsky Nizhny Novgorod State University
Email: mvedunova@yandex.ru
Russian Federation, Nizhny Novgorod
A. S. Pimashkin
N. I. Lobachevsky Nizhny Novgorod State University
Email: mvedunova@yandex.ru
Russian Federation, Nizhny Novgorod
I. V. Mukhina
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
Russian Federation, Nizhny Novgorod; Nizhny Novgorod
