Antihypoxic and Neuroprotective Effects of Glial Cell-Derived Neurotrophic Factor (GDNF) in Cultures of Dissociated Hippocampal Cells under Conditions of Experimental Hypoxia
- 作者: Vedunova M.1,2, Shishkina T.1,2, Mishchenko T.1,2, Mitroshina E.1,2, Astrakhanova T.1, Pimashkin A.1, Mukhina I.1,2
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隶属关系:
- N. I. Lobachevsky Nizhny Novgorod State University
- Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
- 期: 卷 161, 编号 1 (2016)
- 页面: 168-174
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237237
- DOI: https://doi.org/10.1007/s10517-016-3369-3
- ID: 237237
如何引用文章
详细
We analyzed the effect of glial cell derived neurotrophic factor (GDNF) on changes in functional bioelectric and calcium activity in dissociated hippocampal cell cultures under conditions of modeled acute normobaric hypoxia in vitro. GDNF (1 ng/ml) partially neutralized the negative effects of hypoxia on cell survival and parameters of functional network activity. GDNF exhibited a pronounced anti-hypoxic effect.
作者简介
M. Vedunova
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: mvedunova@yandex.ru
俄罗斯联邦, Nizhny Novgorod; Nizhny Novgorod
T. Shishkina
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
俄罗斯联邦, Nizhny Novgorod; Nizhny Novgorod
T. Mishchenko
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
俄罗斯联邦, Nizhny Novgorod; Nizhny Novgorod
E. Mitroshina
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
俄罗斯联邦, Nizhny Novgorod; Nizhny Novgorod
T. Astrakhanova
N. I. Lobachevsky Nizhny Novgorod State University
Email: mvedunova@yandex.ru
俄罗斯联邦, Nizhny Novgorod
A. Pimashkin
N. I. Lobachevsky Nizhny Novgorod State University
Email: mvedunova@yandex.ru
俄罗斯联邦, Nizhny Novgorod
I. Mukhina
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
俄罗斯联邦, Nizhny Novgorod; Nizhny Novgorod