Enviar artigo por via de e-mail Antihypoxic and Neuroprotective Effects of Glial Cell-Derived Neurotrophic Factor (GDNF) in Cultures of Dissociated Hippocampal Cells under Conditions of Experimental Hypoxia
- Autores: Vedunova M.1,2, Shishkina T.1,2, Mishchenko T.1,2, Mitroshina E.1,2, Astrakhanova T.1, Pimashkin A.1, Mukhina I.1,2
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Afiliações:
- N. I. Lobachevsky Nizhny Novgorod State University
- Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
- Edição: Volume 161, Nº 1 (2016)
- Páginas: 168-174
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237237
- DOI: https://doi.org/10.1007/s10517-016-3369-3
- ID: 237237
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Resumo
We analyzed the effect of glial cell derived neurotrophic factor (GDNF) on changes in functional bioelectric and calcium activity in dissociated hippocampal cell cultures under conditions of modeled acute normobaric hypoxia in vitro. GDNF (1 ng/ml) partially neutralized the negative effects of hypoxia on cell survival and parameters of functional network activity. GDNF exhibited a pronounced anti-hypoxic effect.
Sobre autores
M. Vedunova
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: mvedunova@yandex.ru
Rússia, Nizhny Novgorod; Nizhny Novgorod
T. Shishkina
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
Rússia, Nizhny Novgorod; Nizhny Novgorod
T. Mishchenko
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
Rússia, Nizhny Novgorod; Nizhny Novgorod
E. Mitroshina
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
Rússia, Nizhny Novgorod; Nizhny Novgorod
T. Astrakhanova
N. I. Lobachevsky Nizhny Novgorod State University
Email: mvedunova@yandex.ru
Rússia, Nizhny Novgorod
A. Pimashkin
N. I. Lobachevsky Nizhny Novgorod State University
Email: mvedunova@yandex.ru
Rússia, Nizhny Novgorod
I. Mukhina
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
Rússia, Nizhny Novgorod; Nizhny Novgorod
