Отправить статью по E-mail Antihypoxic and Neuroprotective Effects of Glial Cell-Derived Neurotrophic Factor (GDNF) in Cultures of Dissociated Hippocampal Cells under Conditions of Experimental Hypoxia
- Авторы: Vedunova M.1,2, Shishkina T.1,2, Mishchenko T.1,2, Mitroshina E.1,2, Astrakhanova T.1, Pimashkin A.1, Mukhina I.1,2
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Учреждения:
- N. I. Lobachevsky Nizhny Novgorod State University
- Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
- Выпуск: Том 161, № 1 (2016)
- Страницы: 168-174
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237237
- DOI: https://doi.org/10.1007/s10517-016-3369-3
- ID: 237237
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Аннотация
We analyzed the effect of glial cell derived neurotrophic factor (GDNF) on changes in functional bioelectric and calcium activity in dissociated hippocampal cell cultures under conditions of modeled acute normobaric hypoxia in vitro. GDNF (1 ng/ml) partially neutralized the negative effects of hypoxia on cell survival and parameters of functional network activity. GDNF exhibited a pronounced anti-hypoxic effect.
Об авторах
M. Vedunova
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: mvedunova@yandex.ru
Россия, Nizhny Novgorod; Nizhny Novgorod
T. Shishkina
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
Россия, Nizhny Novgorod; Nizhny Novgorod
T. Mishchenko
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
Россия, Nizhny Novgorod; Nizhny Novgorod
E. Mitroshina
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
Россия, Nizhny Novgorod; Nizhny Novgorod
T. Astrakhanova
N. I. Lobachevsky Nizhny Novgorod State University
Email: mvedunova@yandex.ru
Россия, Nizhny Novgorod
A. Pimashkin
N. I. Lobachevsky Nizhny Novgorod State University
Email: mvedunova@yandex.ru
Россия, Nizhny Novgorod
I. Mukhina
N. I. Lobachevsky Nizhny Novgorod State University; Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation
Email: mvedunova@yandex.ru
Россия, Nizhny Novgorod; Nizhny Novgorod
