Long-term results of corneal collagen crosslinking for recurrent corneal erosion
- Authors: Novikov S.A.1, Tkachenko N.V.1, Frolov O.A.2, Seyfeddin A.S.1
-
Affiliations:
- I.P. Pavlov First Saint Petersburg State Medical University
- Diagnostic Center No. 7 (Eye) for Adults and Children
- Issue: Vol 14, No 1 (2021)
- Pages: 15-24
- Section: Original researches
- URL: https://journals.rcsi.science/ov/article/view/61269
- DOI: https://doi.org/10.17816/OV61269
- ID: 61269
Cite item
Abstract
BACKGROUND: Recurrent corneal erosion (RCE) is characterized by excacerbation and remission episodes, reduced patient’s quality of life affecting their daily and professional activities. In case of conservative therapy inefficacy surgical procedures are used (Bowman’s membrane polishing with diamond drill, excimer laser phototherapeutic keratectomy, anterior stromal puncture, and amniotic membrane transplantation). All methods have their advantages and weak points, as well as a certain percent of recurrence. In this regard the use of corneal collagen cross-linking is of the interest as an alternative method of the RCE surgical treatment.
MATERIALS AND METHODS: 18 patients (20 eyes) with RCE without central corneal stroma scars, aged from 30 to 66 (average 49,5 ± 10,6, all women), after conservative treatment failure (more than 6 months) underwent cross-linking according to the Dresden protocol with the UVX device, version 1000, by IROC INNOCROSS (Switzerland).
RESULTS: All patients were asymptomatic and had no recurrence during the observation period (from 1 to 6 years, in average 2,6 ± 1,6). There was a slight but statistically significant BCVA improvement (from 0,93 ± 0,09 at baseline to 0,97 ± 0,07 after intervention).
CONCLUSIONS: Crosslinking may be an additional and effective treatment in a number of RCE cases when there is no central corneal stromal scars present. To reduce stromal keratocytes alteration during the procedure modified protocols may be used.
Full Text
##article.viewOnOriginalSite##About the authors
Sergey A. Novikov
I.P. Pavlov First Saint Petersburg State Medical University
Email: serg2705@yandex.ru
SPIN-code: 4770-7090
MD, PhD, DMedSc, Professor
Russian Federation, 6–8 L’va Tolstogo str., Saint Petersburg, 197022Natalya V. Tkachenko
I.P. Pavlov First Saint Petersburg State Medical University
Email: natalyatkachenko@yandex.ru
SPIN-code: 5187-3670
MD, PhD, Assistant
Russian Federation, 6–8 L’va Tolstogo str., Saint Petersburg, 197022Oleg A. Frolov
Diagnostic Center No. 7 (Eye) for Adults and Children
Email: oleg524@mail.ru
ORCID iD: 0000-0002-0162-5454
Postgraduate student
Russian Federation, Saint PetersburgAkhmed S. Seyfeddin
I.P. Pavlov First Saint Petersburg State Medical University
Author for correspondence.
Email: dr.aseifeddine@gmail.com
ORCID iD: 0000-0003-1789-4269
Postgraduate student
Russian Federation, 6–8 L’va Tolstogo str., Saint Petersburg, 197022References
- Miller D, Hasan S, Simmons N. Recurrent corneal erosion: a comprehensive review. Clinical Ophthalmology. 2019;13:325–335. doi: 10.2147/OPTH.S157430
- Pronkin IA, Maychuk DY. Recurrent corneal erosion: etiology, pathogenesis, diagnosis and treatment. Fyodorov Journal of Ophthalmic Surgery. 2015;(1):62–67. (In Russ.)
- Wood O. Reccurrent erosion. Trans Am Ophthalmol Soc. 1984;82:850-898.
- Hammar B, Lagali N, Ek S, et al. Dystrophia Smolandiensis – recurrent corneal erosions with a novel morphological picture. Acta Ophthalmologica. 2010;88:394–400. doi: 10.1111/j.1755-3768.2009.01548.x
- Gipson IK. Adhesive mechanisms of the corneal epithelium. Acta Ophthalmol Suppl. 1992;(202):13–17. doi: 10.1111/j.1755-3768.1992.tb02162.x
- Hykin PG, Foss AE, Pavesio C, Dart JK. The natural history and management of recurrent corneal erosion: a prospective randomised trial. Eye. 1994;8:35–40. DIO: 10.1038/eye.1994.6
- Tkachenko NV, Ramazanova AM, Rakhmanov VV. Clinical case of Cogan corneal distrophy: modern approaches to diagnosis and treatment. Ophtalmol. vedom. 2012;5(3):83–90. (In Russ.)
- Eschstruth P, Sekundo W. Recurrent corneal erosion. Different treatment options with the excimer laser with emphasis on agressive PTK. Ophthalmologe. 2006;103(7):570–575. doi: 10.1007/s00347-006-1362-3
- Das S, Seitz B. Recurrent corneal erosion syndrome. Surv Ophthalmol. 2008;53(1):3–15. doi: 10.1016/j.survophthal.2007.10.011
- Aitken DA, Beirouty ZA, Lee WR. Ultrastructural study of the corneal epithelium in the recurrent erosion syndrome. Br J Ophthalmol. 1995;79(3):282–289. doi: 10.1136/bjo.79.3.282
- Chandler P. Recurrent corneal erosion of the cornea. Trans Am Ophthalmol Soc. 1944;44:355–371. doi: 10.1016/0002-9394(45)90937-8
- Kucherenko AM, Shulzhenko DV, Kuznetsova SM, et al. Association of IL8 and IL10 gene allelic variants with ischemic stroke risk and prognosis. Biopolymers and Cell. 2014;47(3):4245. (In Russ.)
- Garrana RM, Zieske JD, Assouline M, Gipson IK. Matrix metalloproteinases in epithelia from human epithelial recurrent erosion. Invest Ophthalmol Vis Science. 1999;40(6):1266–1270.
- Lowe R. Recurrent erosion of the cornea. Br J Ophthalmol. 1970;54(12):805–809. doi: 10.1136/bjo.54.12.805
- Trufanov SV, Malozhen SA, Polunina EG, et al. Reсurrent corneal erosion syndrome (a review). Ophthalmology in Russia. 2015;12(2):4–12. (In Russ.) doi: 10.18008/1816-5095-2015-2-4-12
- Thakrar R, Hemmati H. Treatment of recurrent corneal erosions. Eyenet Magazine. 2013;3:39–41.
- Brown N, Bron A. Recurrent erosion of the cornea. Br J Ophthalmol. 1976;60(2):84–96. doi: 10.1136/bjo.60.2.84
- del Castillo JM, de la Casa JM, Sardina RC, et al. Treatment of recurrent corneal erosions using autologous serum. Cornea. 2002;21(8):781–783. doi: 10.1097/00003226-200211000-00010
- Fujikawa LS, Foster CS, Harrist TJ, et al. Fibronectin in healing rabbit corneal wounds. Lab Invest. 1981;45(2):120–129.
- Kent HD, Cohen EJ, Laibson PR, Arentsen JJ. Microbial keratitis and corneal ulceration associated with therapeutic soft contact lenses. CLAO J. 1990;16(1):49–52.
- Poland DE, Kaufman HE. Clinical uses of collagen shields. J Cataract Refract Surg. 1988;14(5):489–491. doi: 10.1016/S0886-3350(88)80003-8
- Ling J, Gire A, Pflugfelder S. PROSE therapy used to minimise corneal trauma in patients with corneal epithelial defects. Am J Ophthalmol. 2013;155(4):615–619. doi: 10.1016/j.ajo.2012.09.033
- Dursun D, Kim MC, Solomon A, Pflugfelder SC. Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. Am J Ophthalmol. 2001;132:8–13. doi: 10.1016/s0002-9394(01)00913-8
- Dua HS, Lagnado R, Raj D, et al. Alcohol delamination of the corneal epithelium: an alternative in the management of recurrent corneal erosions. Ophthalmology. 2006;113(3):404–411. doi: 10.1016/j.ophtha.2005.10.049
- Wong VW, Chi SC, Lam DS. Diamond burr polishing for recurrent corneal erosions: results from a prospective randomized controlled trial. Cornea. 2009;28(2):152–156. doi: 10.1097/ico.0b013e31818526ec
- Vo RC, Chen JL, Sanchez PJ, et al. Long-term outcomes of epithelial debridement and Diamond Burr polishing for corneal epithelial irregularity and recurrent corneal erosion. Cornea. 2015;34(10):1259–1265. doi: 10.1097/ico.0000000000000554
- Jaun S, Austin DJ. Phototherapeutic keratectomy for the treatment of recurrent corneal erosions. Cataract Refract Surg. 1999;25(12):1610–1614. doi: 10.1136/bjo.86.3.270
- Pogorelov P, Langenbucher A, Kruse F, et al. Long-term results of phototherapeutic keratectomy for corneal map-dot-fingerprint dystrophy (Cogan-Guerry). Cornea. 2006;25(7):774–777. doi: 10.1097/01.ico.0000214801.02195.d4
- McLean EN, MacRae SM, Rich LF. Recurrent erosion. Treatment by anterior stromal puncture. Ophthalmology. 1986;93(6): 784–788.
- Reidy JJ, Paulus MP, Gona S. Recurrent erosions of the cornea: epidemiology and treatment. Cornea. 2000;19(6):767–771. doi: 10.1097/00003226-200011000-00001
- Geggel HS. Successful treatment of recurrent corneal erosion with Nd: YAG anterior stromal puncture. Am J Ophthalmol. 1990;110(4):404–7. doi: 10.1016/s0002-9394(14)77021-7
- Buxton JN, Constad WH. Superficial epithelial keratectomy in the treatment of epithelial basement membrane dystrophy. Ann Ophthalmol. 1987;19(3):92–96.
- Suri K, Kosker M, Duman F, et al. Demographic patterns and treatment outcomes of patients with recurrent corneal erosions related to trauma and epithelial and Bowman layer disorders. Am J Ophthalmol. 2013;156(6):1082–1087. doi: 10.1016/j.ajo.2013.07.022
- Ohman L, Fagerholm P, Tengroth B. Treatment of recurrent corneal erosions with the excimer laser. Acta Ophthalmol. 1994;72(4):461–463. doi: 10.1111/j.1755-3768.1994.tb02797.x
- Elmoddather M. Phototherapeutic keratectomy versus corneal cross linking for treatment of recurrent corneal erosion. AAMJ. 2013;11(3):261–268.
- Maini R, Loughnan MS. Phototherapeutic keratectomy re-treatment for recurrent corneal erosion syndrome. Br J Ophthalmol. 2002;86(3):270–272. doi: 10.1136/bjo.86.3.270
- Sridhar MS, Rapuano CJ, Cosar CB, et al. Phototherapeutic keratectomy versus diamond burr polishing of Bowman’s membrane in the treatment of recurrent corneal erosions associated with anterior basement membrane dystrophy. Ophthalmology. 2002;109(4): 674–679. doi: 10.1016/s0161-6420(01)01027-2
- Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Cornea. 2003;135(5):620–627. doi: 10.1016/S0002-9394(02)02220-1
- Tabibian D, Richoz O, Hafezi F. PACK-CXL: Corneal Cross-linking for Treatment of Infectious Keratitis. J Ophthalmic Vis Res. 2015;10(1):77–80. doi: 10.4103/2008-322X.156122
- Wollensak G, Aurich H, Wirbelauer C, Pham DT. Potential use of riboflavin/UVA cross-linking in bullous keratopathy. Ophthalmic Res. 2009;41(2):114–117. doi: 10.1159/000187630
- Salmon AG. Corneal cross-linking for treatment of recurrent dystrophic corneal erosion. Ophthalmol Soc Egypt. 2012;105: 31–35.
- Huang Y, Kheirkhah A, Tseng S. Placement ProKera for Recurrent Corneal Erosion. Investigative Ophthalmology & Visual Science. 2012;53:3569.
![](/img/style/loading.gif)