角膜胶原交联术治疗复发性角膜糜烂的长期效果

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前言: 复发性角膜糜烂（RCE）的特点是病情加重和缓解交替出现，大大降低了患者的生活质量，使其日常生活和工作变得困难。在保守治疗效果不佳的情况下，可采用手术方法：金刚石钻针抛光、光学治疗性角膜切削术、前基质层穿刺术、羊膜移植术。每种方法都有其优点和缺点，也有一定的复发率。在这方面，角膜胶原交联（CCL）的使用在寻找RCE手术治疗的替代方法中很有意义。

材料和方法: 18名30至66岁的RCE患者（平均年龄在49.5±10.6岁），在保守治疗无效的情 况下（超过6个月），按照德累斯顿协议在UV X 1000的设备上（IROC INNOCROSS公司（瑞士））进行了CCL。

结果: 在观察期间（1至6年，平均2.6±1.6年），所有患者的RCE症状完全缓解，没有复发。最大矫正视力有轻微但有统计学意义的增加（CCL前0.93±0.09/后0.97±0.07）。

结论: 在中央基质没有混浊的情况下，CCL可能是一种额外的、有效的RCE治疗方法。在未来，最好使用改良的交联技术，控制其影响的深度，以避免对基质角质细胞产生不利 的影响。

作者简介

Sergey Novikov

I.P. Pavlov First Saint Petersburg State Medical University

Email: serg2705@yandex.ru
SPIN 代码: 4770-7090

MD, PhD, DMedSc, Professor

俄罗斯联邦, 6–8 L’va Tolstogo str., Saint Petersburg, 197022

Natalya Tkachenko

I.P. Pavlov First Saint Petersburg State Medical University

Email: natalyatkachenko@yandex.ru
SPIN 代码: 5187-3670

MD, PhD, Assistant

俄罗斯联邦, 6–8 L’va Tolstogo str., Saint Petersburg, 197022

Oleg Frolov

Diagnostic Center No. 7 (Eye) for Adults and Children

Email: oleg524@mail.ru
ORCID iD: 0000-0002-0162-5454

Postgraduate student

俄罗斯联邦, Saint Petersburg

Akhmed Seyfeddin

I.P. Pavlov First Saint Petersburg State Medical University

编辑信件的主要联系方式.
Email: dr.aseifeddine@gmail.com
ORCID iD: 0000-0003-1789-4269

Postgraduate student

俄罗斯联邦, 6–8 L’va Tolstogo str., Saint Petersburg, 197022

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