Dynamics of vitreoretinal interface changes in diabetic macular edema during regular antiangiogenic therapy

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Abstract

In the study, the state of the vitreoretinal interface (VRI) was investigated in diabetic macular edema (DME) at primary diagnosis and during regular antiangiogenic ranibizumab therapy. At primary diagnosis, pathological VRI changes were detected in 49.3% of cases. During regular antiangiogenic therapy, the transformation of initially normal VRI into pathological one occurs in 6% of cases, the transformation of initially pathological VRI into normal or other pathological one – in 15.8%. Initially pathological VRI is not an absolute indication for vitrectomy, since in no fewer than 7.9% of cases its transformation into normal VRI is possible.

About the authors

Dzhambulat H. Oskanov

S.N. Fedorov NMRC “MNTK “Eye Microsurgery”

Author for correspondence.
Email: oskanovd@mail.ru
ORCID iD: 0000-0001-8842-2643
SPIN-code: 9853-5775

Ophthalmologist

Russian Federation, Saint Petersburg

Sergei V. Sosnovskii

S.N. Fedorov NMRC “MNTK “Eye Microsurgery”

Email: svsosnovsky@mail.ru

Assistant-Professor, PhD, MD of Highest Qualification, Ophthalmologist

Russian Federation, Saint Petersburg

Ernest V. Boiko

S.N. Fedorov NMRC “MNTK “Eye Microsurgery”; North-Western State Medical University named after I.I. Mechnikov; Military Medical Academy named after S.M. Kirov

Email: boiko111@list.ru

Professor, Doctor of Medical Science, Honored MD of Russian Federation, Director; Professor, Head, Ophthalmology Department

Russian Federation, Saint Petersburg

Roman D. Berezin

S.N. Fedorov NMRC “MNTK “Eye Microsurgery”

Email: berrom@yandex.ru

PhD, Ophthalmologist

Russian Federation, Saint Petersburg

Tat’yana V. Kotsur

S.N. Fedorov NMRC “MNTK “Eye Microsurgery”

Email: tatiana781@yandex.ru

MD, Ophthalmologist. Laser Microsurgery and Fluorescent Angiography Department

Russian Federation, Saint Petersburg

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Supplementary files

Supplementary Files
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2. Fig. 1. Types of pathological vitreoretinal interface in DME

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3. Fig. 2. Quantitative and fractional distribution of VRI types at the initial diagnosis and during antiangiogenic therapy of DME

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4. Fig. 3. The number of VRI type change cases in DME 1 month after intravitreal administration of angiogenesis inhibitor

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5. Fig. 4. Times of VRI type transitions

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6. Fig. 5. The number of intravitreal angiogenesis inhibitor administrations before the transformation into another vitreoretinal interface type in DME

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Copyright (c) 2020 Oskanov D.H., Sosnovskii S.V., Boiko E.V., Berezin R.D., Kotsur T.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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