Ciclosporin use for prevention of pterygium recurrence

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Abstract

BACKGROUND: Despite the development of new methods for treatment of pterygium, the frequency of its recurrence ranges from 5 to 89%.

AIM: Was to evaluate the effectiveness of ciclosporin for prevention of pterygium recurrence.

MATERIALS AND METHODS: Under follow-up, there were 104 patients operated for pterygium, of which 26 had a high risk of recurrence, they were divided into 2 groups: the 1st group — 13 patients received 0.05% ciclosporin in addition to basic therapy; the 2nd group — 13 patients receiving only basic therapy. Patients of studied groups were under dynamic observation for 1 year.

RESULTS: After 3 months, all patients of the 1st group showed normalization of the osmolarity of the lacrimal fluid (OLF) and the ocular surface disease index (OSDI). In patients of the 2nd group, elevated values of OLF and OSDI remained characterizing the persistence of an inflammatory reaction signs and a high risk of the disease recurrence, as well as the formation of a hypertrophic scar in 38.5% of cases. In one year after surgery, 3 patients of group 2 had a recurrent pterygium, which required surgical retreatment.

CONCLUSIONS: We obtained results showing a positive effect of ciclosporin use on dynamics of inflammatory reactions of the ocular surface in postoperative period, which made it possible to prevent pterygium recurrence after its surgical treatment in patients with high risk of recurrence.

About the authors

Anna N. Bochkareva

S.N. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch

Author for correspondence.
Email: naukakhvmntk@mail.ru
ORCID iD: 0000-0002-3575-0894
SPIN-code: 2765-4299

Ophthalmologist

Russian Federation, Khabarovsk

Oleg V.  Kolenko

S.N. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch; Postgraduate Institute for Public Health Workers

Email: naukakhvmntk@mail.ru
ORCID iD: 0000-0001-7501-5571
SPIN-code: 5775-5480
Scopus Author ID: 6506683725

Dr. Sci. (Med.), Director

Russian Federation, Khabarovsk; Khabarovsk

Victor V. Egorov

S.N. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch; Postgraduate Institute for Public Health Workers

Email: naukakhvmntk@mail.ru
ORCID iD: 0000-0002-9888-7353
SPIN-code: 9253-3870
Scopus Author ID: 7202505024

Dr. Sci. (Med.), Professor, General Consultant

Russian Federation, Khabarovsk; Khabarovsk

Galina P. Smoliakova

S.N. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch; Postgraduate Institute for Public Health Workers

Email: naukakhvmntk@mail.ru
ORCID iD: 0000-0002-6943-5518
SPIN-code: 8667-1885
Scopus Author ID: 6701803515

MD, Dr. Sci. (Med.), Professor, Ophthalmologist

Russian Federation, Khabarovsk; Khabarovsk

Pavel A. Banshchikov

S.N. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch

Email: naukakhvmntk@mail.ru
ORCID iD: 0000-0002-0854-4104
SPIN-code: 5105-9233
Scopus Author ID: 57201736974

MD, Cand. Sci. (Med.), Head of the Reconstructive Surgery Department, Ophthalmologist

Russian Federation, Khabarovsk

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Supplementary files

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2. Fig. 1. A patient from the 1st group. 3 months after pterygium surgery: in the area of the procedure, a normotrophic scar is present, not rising above the surface, vessels have a rectilinear and uniform course

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3. Fig. 2. A patient from the 2nd group. 3 months after pterygium surgery: a hypertrophic scar with pronounced vascular activity in limbus is found in the operation area (uneven course and caliber of vessels, microaneurysms)

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Copyright (c) 2022 Bochkareva A.N., Kolenko O.V., Egorov V.V., Smoliakova G.P., Banshchikov P.A.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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