Ciclosporin use for prevention of pterygium recurrence

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BACKGROUND: Despite the development of new methods for treatment of pterygium, the frequency of its recurrence ranges from 5 to 89%.

AIM: Was to evaluate the effectiveness of ciclosporin for prevention of pterygium recurrence.

MATERIALS AND METHODS: Under follow-up, there were 104 patients operated for pterygium, of which 26 had a high risk of recurrence, they were divided into 2 groups: the 1st group — 13 patients received 0.05% ciclosporin in addition to basic therapy; the 2nd group — 13 patients receiving only basic therapy. Patients of studied groups were under dynamic observation for 1 year.

RESULTS: After 3 months, all patients of the 1st group showed normalization of the osmolarity of the lacrimal fluid (OLF) and the ocular surface disease index (OSDI). In patients of the 2nd group, elevated values of OLF and OSDI remained characterizing the persistence of an inflammatory reaction signs and a high risk of the disease recurrence, as well as the formation of a hypertrophic scar in 38.5% of cases. In one year after surgery, 3 patients of group 2 had a recurrent pterygium, which required surgical retreatment.

CONCLUSIONS: We obtained results showing a positive effect of ciclosporin use on dynamics of inflammatory reactions of the ocular surface in postoperative period, which made it possible to prevent pterygium recurrence after its surgical treatment in patients with high risk of recurrence.

作者简介

Anna Bochkareva

S.N. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch

编辑信件的主要联系方式.
Email: naukakhvmntk@mail.ru
ORCID iD: 0000-0002-3575-0894
SPIN 代码: 2765-4299

Ophthalmologist

俄罗斯联邦, Khabarovsk

Oleg Kolenko

S.N. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch; Postgraduate Institute for Public Health Workers

Email: naukakhvmntk@mail.ru
ORCID iD: 0000-0001-7501-5571
SPIN 代码: 5775-5480
Scopus 作者 ID: 6506683725

Dr. Sci. (Med.), Director

俄罗斯联邦, Khabarovsk; Khabarovsk

Victor Egorov

S.N. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch; Postgraduate Institute for Public Health Workers

Email: naukakhvmntk@mail.ru
ORCID iD: 0000-0002-9888-7353
SPIN 代码: 9253-3870
Scopus 作者 ID: 7202505024

Dr. Sci. (Med.), Professor, General Consultant

俄罗斯联邦, Khabarovsk; Khabarovsk

Galina Smoliakova

S.N. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch; Postgraduate Institute for Public Health Workers

Email: naukakhvmntk@mail.ru
ORCID iD: 0000-0002-6943-5518
SPIN 代码: 8667-1885
Scopus 作者 ID: 6701803515

MD, Dr. Sci. (Med.), Professor, Ophthalmologist

俄罗斯联邦, Khabarovsk; Khabarovsk

Pavel Banshchikov

S.N. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch

Email: naukakhvmntk@mail.ru
ORCID iD: 0000-0002-0854-4104
SPIN 代码: 5105-9233
Scopus 作者 ID: 57201736974

MD, Cand. Sci. (Med.), Head of the Reconstructive Surgery Department, Ophthalmologist

俄罗斯联邦, Khabarovsk

参考

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2. Fig. 1. A patient from the 1st group. 3 months after pterygium surgery: in the area of the procedure, a normotrophic scar is present, not rising above the surface, vessels have a rectilinear and uniform course

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3. Fig. 2. A patient from the 2nd group. 3 months after pterygium surgery: a hypertrophic scar with pronounced vascular activity in limbus is found in the operation area (uneven course and caliber of vessels, microaneurysms)

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版权所有 © Bochkareva A., Kolenko O., Egorov V., Smoliakova G., Banshchikov P., 2022

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