The state of the circulatory, respiratory and hemostasis organs of the servisemen, suffered from coronavirus pneumonia, in a remote recovery period
- Authors: Serdyukov D.Y.1, Rodichev N.S.1, Tretyakovа A.A.1
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Affiliations:
- S.M. Kirov Military Medical Academy
- Issue: Vol 40, No 3 (2021)
- Pages: 27-32
- Section: Original articles
- URL: https://journals.rcsi.science/RMMArep/article/view/77051
- DOI: https://doi.org/10.17816/rmmar77051
- ID: 77051
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Abstract
The problem of the long-term effects of COVID-19, especially its severe forms, is already acutely relevant for world healthcare. Severe course of the novel coronavirus infection (“cytokine storm”) may be accompanied with the damage of respiratory system, circulatory system, and hemostasis.
In the Department of Hospital Therapy Military Medical Academy have been examined 64 servicemen: 1st group of 44 people aged 46.1 ± 7 years with developed “cytokine storm”; 2nd group — 20 men 47 ± 4.4 years without this complication. Patients were screened and treated under the standard scheme; 3 months after discharge from the hospital, respiratory, heart failure and D-dimer levels were assessed.
There was a significant increase pulmonary damage with decrease in saturation to 92.3 % (p = 0.003) in the 1st group; laboratory signs of myocardial lesions: increase of troponin T to 15.4 ng/l (p = 0.001), a significant increase in the total creatine phosphokinase, aspartate amine transferase and alanine aminotransferase compared to patients of the 2nd group. The average rates of standard hemogram, with the exception of platelet levels (173 × 103/l, p = 0.03) in the 1st group were no different from similar parameters of patients from the 2nd group. It was drawn to attention the reliable increase in C-reactive protein, D-dimer and ferritin in men of the 1st group. During the reexamination after 3 months more often diagnosed the phenomenon of respiratory and heart failure and hypercoagulation in patients from the 1st group, which dictates the need for further dynamic monitoring of this category (1 figure, 2 tables, bibliography: 14 refs).
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##article.viewOnOriginalSite##About the authors
Dmitriy Yu. Serdyukov
S.M. Kirov Military Medical Academy
Author for correspondence.
Email: serdukovdu@yandex.ru
ORCID iD: 0000-0002-3782-1289
SPIN-code: 1870-8698
M.D., D.Sc. (Medicine)
Russian Federation, 6, Akademika Lebedeva str., Saint Petersburg, 194044Nikolay S. Rodichev
S.M. Kirov Military Medical Academy
Email: nig27@mail.ru
ORCID iD: 0000-0002-9630-6770
Russian Federation, 6, Akademika Lebedeva str., Saint Petersburg, 194044
Anastasiya A. Tretyakovа
S.M. Kirov Military Medical Academy
Email: nastya95bravo@mail.ru
ORCID iD: 0000-0001-6231-2112
SPIN-code: 7030-4289
Russian Federation, 6, Akademika Lebedeva str., Saint Petersburg, 194044
References
- Belyakov NA, Rassokhin VV, Yastrebova EB. Coronavirus infectious disease COVID-19. Nature of virus, pathogenesis, clinical manifestations. Report 1. HIV Infection and Immunosuppressive Disorders. 2020;12(1):7–21. (In Russ.)
- Interim Guidelines: Prevention, Diagnosis and Treatment of Novel Coronavirus Infection (COVID-19). Version 11 from 07.05.2021. Moscow; 2021. 225 р. (In Russ.)
- Diagnostics, treatment, and prevention of new coronavirus infection (COVID-19). Methodical recommendations, approved by early Main Military Medical University of the Ministry of Defense of the Russian Federation 26.03.2020. Moscow; 2020. 54 p. (In Russ.)
- Khirmanov VN. COVID-19 as a systemic disease. Clinical pharmacology and therapy. 2021;30(1):5–15. (In Russ.) doi: 10.32756/0869-5490-2021-1-5-15
- Chen L, Li X, Chen M, Feng Y, Xiong C. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res. 2020;116(6):1097–1100. doi: 10.1093/cvr/cvaa078
- Kryukov EV., Savushkina OI., Chernyak AV., Kulagina ITs. Diagnostics of uneven pulmonary ventilation by the method of nitrogen leaching during multiple respiration in patients who have undergone COVID-19. Pulmonology. 2021;31(1):30–36. (In Russ.) doi: 10.18093/0869-0189-2021-31-1-30-36
- Bradley BT, Maioli H, Johnston R, et al. Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series. Lancet. 2020;396(10247):320–332. doi: 10.1016/S0140-6736(20)31305-2
- Kanorskii SG. COVID-19 and the heart: direct and indirect impact. Kubanskiy nauchnyy meditsinskiy vestnik. 2021;28(1):16–31. (In Russ.) doi: 10.25207/1608-6228-2021-28-1-16-31
- Giannis D, Allen SL, Tsang J, et al. Post-Discharge Thromboembolic Outcomes and Mortality of Hospitalized COVID-19 Patients: The CORE-19 Registry. Blood. 2021;137(20):2838–2847. doi: 10.1182/blood.2020010529
- Fayol A, Livrozet M, Boutouyrie P, et al. Cardiac performance in patients hospitalized with COVID-19: a 6 month follow-up study. ESC Heart Fail. 2021;8(3):2232–2239. doi: 10.1002/ehf2.13315
- Arutyunov GP, Tarlovskaya EI, Arutyunov AG, et al. International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV) and the register “Analysis of hospitalizations of comorbid patients infected during the second wave of SARS-CoV-2 outbreak” (AKTIV 2). Russian Journal of Cardiology. 2021;26(3):4358. (In Russ.) doi: 10.15829/1560-4071-2021-4358
- Ayoubkhani D, Khunti K, Nafilyan V, et al. Post-COVID syndrome in individuals admitted to hospital with COVID-19: retrospective cohort study. BMJ. 2021;372: n693. doi: 10.1136/bmj.n693
- Carfì A, Bernabei R, Landi F. Persistent symptoms in patients after acute COVID-19. JAMA. 2020;324(6):603–605. doi: 10.1001/jama.2020.12603
- Zaitsev AA, Golukhova EZ, Mamalyga ML, et al. The effectiveness of pulse therapy with methylprednisolone in patients with COVID-19. Clinical microbiology and antimicrobial chemotherapy. 2020;22(2):88-91. (In Russ.)
- Zhdanov KV, Kozlov KV, Bulankov YI, et al. Optimization of diagnosis of SARS-CoV-2 infection using polymerase chain reaction in a large multi-specialty hospital. Bulletin of the Russian Military Medical Academy. 2020;22(2):7–10. (In Russ.) doi: 10.17816/brmma50036
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