Email this article SPECIFIC MECHANISMS OF THROMBOSIS FORMATION AT PH-NEGATIVE MYELOPROLIFERATIVE NEW FORMATIONS
- Authors: Serbin A.N1
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Affiliations:
- S.M. Kirov Military Medical Academy of the Ministry of Defense
- Issue: Vol 39, No 1-1S (2020)
- Pages: 151-154
- Section: Articles
- URL: https://journals.rcsi.science/RMMArep/article/view/43397
- DOI: https://doi.org/10.17816/rmmar43397
- ID: 43397
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Abstract
The most relevant Ph-negative myeloproliferative neoplasms (MPN) include: polycythemia vera (PI), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Thrombosis and thromboembolism currently remain the main cause of disability and mortality in MPN. Most modern methods of specific cytoreductive therapy for MPN do not significantly affect the incidence of thrombotic complications, and in some cases may even contribute to their development. Therefore, the use of antithrombotic, primarily antiplatelet, therapy remains the most effective direction of prevention. Currently, various anticoagulants are becoming more common. For their introduction into hematological practice, a clear understanding of the formation of specific mechanisms of pathological thrombosis in MPN is necessary. To this end, we analyzed the disease-specific pathogenetic mechanisms of "thrombophilia" in various Ph-negative MPN.
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##article.viewOnOriginalSite##About the authors
A. N Serbin
S.M. Kirov Military Medical Academy of the Ministry of DefenseSt. Petersburg, Russia
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