PROGNOSTIC SIGNIFICANCE OF 1-HOUR HYPERGLYCEMIA IN YOUNG AGE

At Department of Hospital Therapy Military Medical Academy has been performed prospective study with the participation of 122 st servicemen. Patients after primary carrying out oral glucose tolerance test have been divided into 2 groups: 1 - 60 men with the level of nd glycemia ≥ 8,6 mmol/l after 1 hour of the test; 2 - 62 with a normal 1-hour glycemia. All of the examined patients initially and over time have been evaluated lipid, carbohydrate metabolism, an ultrasound scaning of the heart and of the common carotid arteries. The patients st curation have been realized for 3.8 to 1.5 years. In the initial examination, the two samples were compared in AH (78% vs 74% for the 1 and nd 2 groups, respectively, p>0.05) at average blood pressure values of 156/98 and 153/97 mm Hg. accordingly (p>0.05); AO (42% vs 40%, p>0.05), BMI 29.3 vs 27.4 ± 4.2 kg/m (p=0.015); hypodynamia (42% vs 38%, p>05). Smoking prevailed in men in the 1st group (53 vs 31%, χ =5.0; p=0.02). Against the background of drug therapy, there was an achievement of normotensia in 35 and 46% of patients in the 1 and 2 2 2 st nd groups, respectively (p>0.05); smoking cessation - in 30 and 15% of the subjects (p>05). Alimentary obesity after curation was determined in 67 2 and 50% of men in these subgroups (χ =3,6; p=0.05), which indicated a negative dynamics compared to the initial anthropometric data (p>0.05). Has been identified a number of characteristics for patients with early postprandial hyperglycemia: more atherogenic changes in lipid spectrum, high incidence of prediabetes and diabetes mellitus type 2 in the dynamics. Has been observed more active progression of atherosclerosis as a thickening of the intima-media complex for men with 1-hour hyperglycemia. The presence of 1-hour hyperglycemia is an early marker of development prediabetes and diabetes mellitus type 2, with the result that this indicator should be assessed in everyday clinical practice, along with levels of fasting plasma glucose and 2-hour plasma glucose after postload test.

dyslipidemia, early post-load hyperglycemia, subclinical atherosclerosis, prediabetes, metabolical syndrome, intima-media complex, left ventricular hypertrophy