Effect of galanin on severity of tremor in Parkinson's disease

Objective. To study the effect of galanin on the severity of tremor in Parkinson's disease.

Materials and methods. A comprehensive examination of 73 patients with Parkinson's disease and 16 apparently healthy individuals (control group) was carried out. We used the clinical-anamnestic method, the Hen-Yar scale of movement disorders in Parkinson's disease (PD), the MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Serum galanin content was determined by enzyme immunoassay. Serum galanin was determined by enzyme-linked immunosorbent assay using an ELISA Kit for Galanin (USA). Statistical processing of the material was carried out using the Statistica 10.0 program.

Results. Tremor is one of the main complaints of PD patients. In the main group, the average severity of the disease, subjective and objective manifestations of movement disorders were determined. In patients with PD, a decrease in the quantitative content of blood serum galanin (6.0 [4.3; 10.2] ng / ml) was determined in comparison with the control group (16.9 [9.8; 18.1] ng/ml, p = 0.001). A negative correlation dependence of the galanin content with motor manifestations was revealed in the first (R = –0.8; p = 0, 0001) and second (R = –0.53; p = 0.000002) parts of the MDS-UPDRS, as well as with the severity of resting tremor in the hand (R = –0.81; p = 0.000000) and leg (R = –0.76; p = 0.000001). The dependence of serum galanin on the form of the disease was not obtained in the study.

Conclusions. In Parkinson's disease, there is a decrease in the quantitative content of the neuropeptide galanin in the blood serum, which is negatively associated with motor manifestations of the disease and is associated with the severity of parkinsonian tremor.