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Post a Comment Analysis of L-carnitine effectiveness in complex treat-ment of pregnant women with placental insufficiency
- Authors: Mamedli G.H.1, Babaeva G.I.1, Azizova M.E.1, Sirajli U.M.1, Hajizade G.G.1
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Affiliations:
- Azerbaijan Medical University
- Issue: Vol 38, No 5 (2021)
- Pages: 15-23
- Section: Original studies
- URL: https://journals.rcsi.science/PMJ/article/view/96170
- DOI: https://doi.org/10.17816/pmj38515-23
- ID: 96170
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Abstract
Objective. To increase the effectiveness of treatment of placental insufficiency in pregnant women with the inclusion of L-carnitine (Inestom) in complex therapy.
Materials and methods. A total of 76 pregnant women aged 18 to 39 years were examined at 22–40 weeks of gestation. All the examined patients were divided into two groups. Patients of the first group (n = 37) received only basic treatment, which included the use of a complex of vasodilators, tocolytics, drugs that improve microcirculation and rheological properties of blood. Patients of the second group (n = 39) received L-carnitine along with basic therapy (Inestom, Help SA Pharmaceuticals, Greece).
Results. The use of the drug Inestom as a part of the complex treatment of placental insufficiency led to the normalization of utero-placental-fetal blood flow and intrauterine fetal development in 94.7 % of pregnant women. After the course of drug therapy, there was an increase in the total score of cardiotography, which in the first group of patients was 7.08 ± 0.06 before treatment and 7.13 ± 0.11 after treatment (p > 0.05), and in the second group – 7.12 ± 0.11 before treatment and 7.95 ± 0.05 after (p < 0.05). The results of antenatal dopplerometry showed that in pregnant women who received Inestom as a part of the complex treatment, there was a decrease in the mean values of all vascular resistance indices.
Conclusions. The use of Inestom in the complex treatment of placental insufficiency has a positive effect on the state of hemodynamics in the "mother-placenta-fetus" system, and affects the intrauterine state of the fetus.
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##article.viewOnOriginalSite##About the authors
G. H. Mamedli
Azerbaijan Medical University
Email: dr.azizova@inbox.ru
Candidate of Medical Sciences, Assistant, Department of Obstetrics and Gynecology II
Azerbaijan, BakuG. I. Babaeva
Azerbaijan Medical University
Email: dr.azizova@inbox.ru
Candidate of Medical Sciences, Assistant, Department of Obstetrics and Gynecology II
Azerbaijan, BakuM. E. Azizova
Azerbaijan Medical University
Author for correspondence.
Email: dr.azizova@inbox.ru
Candidate of Medical Sciences, Associate Professor, Department of Obstetrics and Gynecology II
Azerbaijan, BakuU. M. Sirajli
Azerbaijan Medical University
Email: dr.azizova@inbox.ru
Candidate of Medical Sciences, Assistant, Department of Obstetrics and Gynecology II
Azerbaijan, BakuG. G. Hajizade
Azerbaijan Medical University
Email: dr.azizova@inbox.ru
Candidate of Medical Sciences, Assistant, Department of Obstetrics and Gynecology II
Azerbaijan, BakuReferences
- Silva C.M.D., Alves R.S., Santos T.S.D., Bragagnollo G.R., Tavares C.M., Santos A.A.P.D. Epidemiological overview of HIV/AIDS in pregnant women from a state of northeastern Brazil. Rev Bras Enferm 2018; 71 (1): 568–576.
- Silveira M.P., Silveira M.F., Müller C.H. Quality of Life of Pregnant Women Living with HIV/AIDS. Rev Bras Ginecol Obstet 2016; 38(5): 246-252.
- Epidemiological situation as of January 1, 2020 GBUZ Samara Regional Center for the Prevention and Control of AIDS and Infectious Diseases. available at: http://samaraspidcenter.ru/index.php/dlya-spetsialistov/vnimaniyu-spetsialistov (in Russian).
- Decree of the Government of the Russian Federation dated 21.12.2020 No. 3468-r "State Strategy for Countering the Spread of HIV Infection in the Russian Federation for the Period until 2030." Moscow 2020: 21 (in Russian).
- Pregravidic training. Clinical protocol of the Interdisciplinary Association of Reproductive Medicine Professionals (MARS).
- Version 2.0. Moscow: StatusPraesens 2020: 128 (in Russian).
- Zajcev V.M., Lifljandskij V.G., Marinkin V.I. Applied medical statistics: Uchebnoe posobie. Saint Petersburg: Foliant 2006: 262–286 (in Russian).
- Vinogradova E.V. Prediction and prevention of vertical transmission of HIV infection from mother to fetus: avtoref. dis. … kan. med. nauk. Samara 2011 (in Russian).
- Berard A.R, Perner M., Mutch S., Farr Zuend C., McQueen P., Burgener A.D. Understanding mucosal and microbial functionality of the female reproductive tract by metaproteomics: Implications for HIV transmission. Am J Reprod Immunol 2018; 80: 12977.
- Chetty T., Newell M.L., Thorne C., Coutsoudis A. Viraemia before, during and after pregnancy in HIV-infected women on antiretroviral therapy in rural KwaZulu-Natal, South Africa, 2010–2015. Trop Med Int Health 2017; 23(1): 79–91.
- Kakkar F., Lamarre V., Ducruet T., Boucher M., Valois S., Soudeyns H., Lapointe N. Impact of maternal HIV-1 viremia on lymphocyte subsets among HIV-exposed uninfected infants: protective mechanism or immunodeficiency. BMC Infect Dis 2014; 14: 236.
- Huramshin F.Sh. Effects of HIV infection on pregnancy, childbirth, postpartum and effects of pregnancy on HIV infection. Tavricheskij mediko-biologicheskij vestnik 2011; 14 (3): 291–294 (in Russian).
- Mihal'chenko S.V., Ovchinnikova A.O. Reproductive choices of HIV-infected women: pregnancy planning. Vestnik medicinskogo instituta «Reaviz»: reabilitacija, vrach i zdorov'e 2017: 4: 28–32 (in Russian).
- García-Otero L., López M., Gómez O., Goncé A., Bennasar M., Martínez J.M., Valenzuela-Alcaraz B., Rodriguez-López M., Sitges M., Loncà M., Bijnens B., Crispi F., Gratacós E. Zidovudine treatment in HIV-infected pregnant women is associated with fetal cardiac remodelling. AIDS 2016; 30 (9): 1393–1401.
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