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Post a Comment Effect of pregravid preparation of HIV-infected couples on perinatal outcomes
- Authors: Ovchinnikova A.O.1, Mikhalchenko S.V.1, Kaganova M.A.1, Chernova O.E.2
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Affiliations:
- Samara State Medical University
- Samara Regional Clinical Center for AIDS Prevention and Control
- Issue: Vol 38, No 5 (2021)
- Pages: 6-14
- Section: Original studies
- URL: https://journals.rcsi.science/PMJ/article/view/96085
- DOI: https://doi.org/10.17816/pmj3856-14
- ID: 96085
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Abstract
Objective. To assess the levels of viral load, immune status as well as labor outcome depending on the absence or presence of pregravid preparation with the partner and without the latter.
Materials and methods. This cohort study included 90 women of reproductive age with stages 3 and 4A HIV infection. To compare the groups, Kruskal – Wallis, Mann – Whitney tests and correlation analysis were applied.
Results. The pregravid preparation of HIV-infected women without a partner was detected to three-fold decrease a viral load in the I trimester of pregnancy (p = 0.001), two-fold – in the II trimester (p = 0.02) and three-fold – in the III trimester (p = 0.002); with a partner – a two-fold decrease in the I trimester (p = 0.0018). The pregravid preparation of HIV-infected women reduces the probability of giving birth to a child with low body mass (p = 0.023); with a partner – it decreases the risk for the preterm labor (p = 0.02).
Conclusions. Thus, the presence of pregravid preparation in HIV-infected women, with a partner as well, decreases the probability of giving birth to a child with low body mass and preterm labor.
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##article.viewOnOriginalSite##About the authors
A. O. Ovchinnikova
Samara State Medical University
Author for correspondence.
Email: aleksaov@bk.ru
Assistant, Department of Obstetrics and Gynecology
Russian Federation, SamaraS. V. Mikhalchenko
Samara State Medical University
Email: aleksaov@bk.ru
MD, PhD, Professor, Department of Obstetrics and Gynecology
Russian Federation, SamaraM. A. Kaganova
Samara State Medical University
Email: aleksaov@bk.ru
Candidate of Medical Sciences, Associate Professor, Department of Obstetrics and Gynecology
Russian Federation, SamaraO. E. Chernova
Samara Regional Clinical Center for AIDS Prevention and Control
Email: aleksaov@bk.ru
Candidate of Medical Sciences, Chief Physician
Russian Federation, SamaraReferences
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