A case of new coronavirus infection course in a child with severe secondary immunodeficiency associated with hematopoietic stem cell transplantation

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Abstract

Numerous articles have been published on COVID-19 cases in the child population now. Children become infected and get sick with a new infection much less often and more easily than adults. The supposed relative resistance of children to SARS-CoV-2 can be explained by a number of reasons, one of which is the immaturity of the ACE2 receptor, or by the fact that children have certain features of innate immunity that disappear in ontogenesis. On the contrary, the maturity of the immune system may explain the unfavorable type of triggered immune response associated with the development of acute respiratory distress syndrome in adult patients.

The article describes a case of a new coronavirus infection in a 5-year-old child with a severe secondary immunodeficiency condition associated with hematopoietic stem cell transplantation. By describing this clinical case, we wanted to draw attention to a mild course of COVID-19 infection in a child with a burdened premorbid history in the form of severe secondary immunodeficiency associated with hematopoietic stem cell transplantation in the treatment of acute promyelocytic leukemia.

About the authors

Natalya Grymova

E.A. Vagner Perm State Medical University

Author for correspondence.
Email: tashagrymova@gmail.com

Candidate of Medical Sciences, Associate Professor, Department of Faculty and Hospital Therapy

Russian Federation, Perm

Ekaterina A. Khuzina

E.A. Vagner Perm State Medical University

Email: eka-khuzina@yandex.ru

Candidate of Medical Sciences, Assistant, Department of Faculty and Hospital Therapy

Russian Federation, Perm

Evgeny G. Furman

E.A. Vagner Perm State Medical University

Email: furman1@yandex.ru

MD, PhD, Professor, Head of Department of Faculty and Hospital Therapy

Russian Federation, Perm

Olga E. Nikonova

Regional Children's Clinical Hospital

Email: noe_pem@mail.ru

Head of Unit of Oncohematology

Russian Federation, Perm

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Copyright (c) 2021 Grymova N., Khuzina E.A., Furman E.G., Nikonova O.E.

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