GENDER PECULIARITIES OF ANTITHROMBOTIC THERAPY IN PATIENTS WITH MYOCARDIAL INFARCTION UNDERGOING TRANSCUTANEOUS CORONARY INTERVENTION

Aim. To ground the individual gender approach to antithrombotic therapy in patients with myocardial infarction undergoing transcutaneous coronary intervention (TCI). Materials and methods. Seventy patients with reliable prevalence of subjects belonging to the senior age categories among women ( n = 30) 71,5 ± 9,8 versus 62,6 ± 13,7 among men ( n = 39) ( p = 0,003) were examined. Results. Combination of such factors as male sex and senior age was revealed to determine a high risk for hemorrhagic complications (CRUSADE) in women as compared to men - 10,0 ± 3,4 versus 6,6 ± 3,4 scores ( p = 0,0001). Among the treated patients, there were no repeated ischemic events, stent thromboses, mild and severe hemorrhagic complications. Taking into account a short period of semiejection and high safety profile of bivalirudin, its administration and inclusion into antithrombotic therapy for patients with elevation of ST segment in the frame of pharmacoinvasive strategy (combination of prehospital thrombolytic therapy and TCI) is most grounded among females. Conclusions. This variant of therapy permits to minimize the risk for development of the postoperative and hemorrhagic complications among women with myocardial infarction.

Myocardial infarction, gender peculiarities, antithrombotic therapy, bivalirudin