SENSITIVITY AND SPECIFICITY OF HYALURONIC ACID, DE RITIS COEFFICIENT AND VASCULOENDOTHELIAL GROWTH FACTOR DETERMINATION FOR DIAGNOSIS OF CHRONIC HEPATITIS AND HEPATIC CIRRHOSIS
- Authors: Schekotova AP1, Bulatova IA1, Roitman AP2
-
Affiliations:
- Пермская государственная медицинская академия им. ак. Е. А. Вагнера
- Российская медицинская академия последипломного образования Минздрава России, г. Москва, Россия
- Issue: Vol 30, No 4 (2013)
- Pages: 84-90
- Section: Articles
- URL: https://journals.rcsi.science/PMJ/article/view/3334
- DOI: https://doi.org/10.17816/pmj30484-90
- ID: 3334
Cite item
Full Text
Abstract
Aim. To compare the possibilities of using blood hyaluronic acid (HA), de Ritis coefficient and vasculoendothelial growth factor (VEGF) determination for diagnosis of hepatic fibrosis in chronic hepatitis and hepatic cirrhosis. Materials and methods. Blood serum HA, aspartic transaminase/ alanine transaminase (AST/ALT) ratio, VEGF were determined in 100 patients with chronic hepatits C and 50 patients with hepatic cirrhosis at the outcome of hepatitis C. The control group included 34 persons. Results. While carrying out correlation analysis, reliable correlations between both direct fibrosis marker – HA and indirect test – de Ritis coefficient and VEGF were revealed. The sensitivity of HA determination for diagnosis of cirrhosis with the concentration higher than 100 ng/ml is 100%, specificity – 80%, negative prognostic value for exclusion of HC – 1,0. The AST/ALT ratio demonstrates 96% sensitivity with the point of division 1,5, specificity – 69%, negative prognostic value – 0,76. The test sensitivity of VEGF determination for differential diagnosis of cirrhosis and hepatitis with the point of division 312,3 pg/ml is 90%, specificity – 80%, efficiency – 84%, negative prognostic value for exclusion of HC – 0,89. Conclusion. Determination of VEGF concentration can be used for differential diagnosis of hepatic cirrhosis and chronic hepatitis as an indirect hepatic fibrosis marker since efficiency of this test somewhat yields to HA and exceeds AST/ALT ratio.
Full Text
##article.viewOnOriginalSite##About the authors
A P Schekotova
Пермская государственная медицинская академия им. ак. Е. А. Вагнера
Email: al_shchekotova@mail.ru
Доцент, доктор мед. наук
I A Bulatova
Пермская государственная медицинская академия им. ак. Е. А. ВагнераАссистент, кандидат мед. наук
A P Roitman
Российская медицинская академия последипломного образования Минздрава России, г. Москва, РоссияДоцент, доктор мед. наук
References
- Власов В. В. Эффективность диагностических исследований. М: Медицина 1988; 256.
- Сафиуллина Н. Х. Диагностическая роль коллагена IV типа и гиалуроновой кислоты в оценке степени воспаления и стадии фиброза печени у больных хроническим гепатитом С: автореф. дис.. канд. мед. наук. М. 2004; 26.
- Щёкотова А. П. Эндотелин-1 – эффективный тест дифференциальной диагностики хронического гепатита и цирроза печени. Пермский медицинский журнал 2012; 1: 55–59.
- Baranova A., Lal P., Birerdinc A., Younossi Z. M. Non-invasive markers for hepatic fibrosis BMC. Gastroenterol. 2011; 11: 91.
- Giannini E., Risso D., Botta F., Chiarbonello B., Fasoli A., Malfatti F., Romagnoli P., Testa E., Ceppa P., Testa R. Validity clinicalutility of the aspartate aminotransferase-alanine aminotransferase ratio in assessing disease sevrity and prognosis in patients with hepatitis C virus-related chronic liver disease. Arch. Intern. Med. 2003; 163(2): 218–224.
- Saadeh S., Cammell G., Carey W. D., Younossi Z., Barnes D., Easley K. The role of liver biopsy in chronic hepatitis C. Hepatology 2001; 33(1): 196–200.
- Wynn А. Cellular and molecular mechanisms of fibrosis. J. Pathol. 2008; 214: 199–210.