PERIODONTAL DISEASES IN HIV-INFECTED PATIENTS: PREVALENCE AND PECULIARITIES OF CLINICAL MANIFESTATIONS DEPENDING ON ADHERENCE TO ANTIRETROVIRAL THERAPY


Cite item

Full Text

Abstract

Aim. To study the prevalence and clinical structure of periodontal diseases in HIV-infected patients depending on adherence to antiretroviral therapy (ART). Materials and methods. The study was based on the results of complex dental examination of 222 HIV-infected patients of “Perm Regional AIDS Center” over the period from 2009 to 2011. Results. Prevalence of classical inflammatory periodontal diseases in HIV-infected patients was 69,7% and that of specific HIV-associated periodontal diseases 27,0%. Patients who underwent antiretroviral therapy had reliably lower prevalence of HIV-associated periodontal diseases and less severe course of classical gingivitis and periodontitis. Conclusion. Dental status of HIV-infected patients is characterized by higher prevalence and intensity of periodontal diseases. Periodontal diseases in HIV-infected patients are characterized by polymorphism, they can be specific and nonspecific, conditioned by typical periodontopathogenic flora. Periodontologic status of HIV-infected patients not adherent to ART is compromised to a greater extent than in subjects receiving the corresponding antiviral therapy.

About the authors

O S Gileva

614000, г. Пермь, ул. Петропавловская, 26, тел. 8 (342) 233 01 92

доктор медицинских наук, профессор, заведующая кафедрой пропедевтики и физиотерапии стоматологических заболеваний

V A Sadilova

614000, г. Пермь, ул. Петропавловская, 26, тел. 8 (342) 233 01 92

Email: verusha_007@mail.ru
аспирант кафедры пропедевтики и физиотерапии стоматологических заболеваний

References

  1. ВИЧ-инфекция в Пермском крае в 2012 г.: справка / Эпидемиологический отдел ГКУЗ ПКЦ СПИД и ИЗ. Пермь 2013.
  2. Гилева О. С., Либик Т. В., Халилаева Е. В., Данилов К. В., Садилова В. А. Стоматологическое здоровье в критериях качества жизни. Медицинский вестник Башкортостана 2011; 3: 6–11.
  3. Гилева О. С., Халилаева Е. В., Либик Т. В., Подгорный Р. В., Халявина И. Н. Многоступенчатая валидация международного опросника качества жизни «Профиль влияния стоматологического здоровья» OHIP-49-RU. Уральский медицинский журнал 2009; 8: 104–109.
  4. Ефимов А. В. Особенности стоматологического статуса ВИЧ-инфицированных в латентной стадии и начальном периоде вторичных заболеваний: автореф. дис. … канд. мед. наук. Пермь 2005; 28.
  5. Лечение ВИЧ-инфекции 2009 / под ред К. Хоффман, Ю. К. Рокшто. М.: Р. Валент 2012; 736.
  6. Практическая терапевтическая стоматология / под ред. А. И. Николаева, Л. М. Цепова. М.: МЕДпресс-информ 2005; 489.
  7. Coogan M., Greenspan J., Challocombe S. Oral lesions in infection with human immunodeficiency virus. Bull. Word Health Organ. 2005; 83: 1–16.
  8. Efimov A., Gileva O., Khaliavina I., Goulyaeva Y., Khalilaeva E. Spectrum of oral manifestations in HIV-infected drug users on highly active antiretroviral therapy (HAART). Hordic-Baltic Oral Medicine meeting. Malmo 2007; 23.
  9. Giacaman R. A., Asrani A. C., Gebhard K. H., Dietrich E. A., Vacharaksa A., Ross A., Herzberg M. C. Porphyromonas gingivalis induces CCR5-dependent transfer of infectious HIV-1 from oral keratinocytes to permissive cells. Retrovirology 2008; 5: 29.
  10. Gileva O., Libik T., Khaliavina I., Goulyaeva Y., Khalilaeva E. Oral health-related quality of life in patients with non-specific ulcero-necrotic oral mucosal lesions. Oral Diseases 2008; 14: 24.
  11. Gileva O. S., Libik T. V., Khalilaeva E. V., Bondarenko E. A. Oral mucosal diseases in HIV-infected Russians on HAART. The 6th World Workshop on Oral Health and Disease in AIDS. China 2009; 88.
  12. Gileva O. S., Sazhina M. V., Gileva E. V., Efimov A. V., Scully C. Spectrum of oral manifestations of HIV/AIDS in the Perm region (Russia) and self-induced ulceronecrotic lingual lesions. Medicina Orale (Spain) 2004; 3 (9): 212–215.
  13. Greenspan D., Greenspan J. Oral complications in HIV infection. Global HIV/AIDS medicine 2008; 215–225.
  14. Huang C. B., Emerson K. F., Gonzalez O. A., Ebersole J. L. Oral bacteria induce a differential activation of human immunodeficiency virus-1 promoter in T cells, macrophages and dendritic cells. Oral. Microbiol. Immunol. 2009; 24: 401–407.
  15. Ryder M. I., Nittayananta W., Coogan M., Greenspan J., Greenspan D. Periodontal dissease in HIV/AIDS. Periodontology 2000 2012; 60: 78–97.
  16. Vaughan J. P., Morrow R. H. Manual of epidemiology for district health management. Geneva: World Health Organization 1989.

Copyright (c) 2013 Gileva O.S., Sadilova V.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies