NEW POSSIBILITIES FOR PROGNOSIS OF ACUTE PANCREATITIS COMPLICATIONS AND ASSESS OF TREATMENT EFFICIENCY

Aim. To study the level and dynamics of changes in blood plasma VEGF and desquamated endotheliocytes (DEC) in patients with severe course of acute pancreatitis both complicated and uncomplicated. Materials and methods. Vascular endothelial growth factor ( VEGF ) and quantity of desquamated endotheliocytes (DEC) were investigated in dynamics in 33 patients with severe acute pancreatitis. These investigations were performed during the first 10 days from the onset of disease and later with the interval of 5–7 days. Patients were divided into 2 groups: group 1 included patients without pyo-septic complications ( n =13), group 2 – patients with pyo-septic complications ( n =20). Results. No reliable differences in DEC number between the groups of patients and between the investigations were revealed. VEGF level in patients with acute pancreatitis is significantly higher than in healthy persons ( p <0,01). Reverse correlation between sepsis severity and blood plasma VEGF level in patients of group 2 was detected (Spirmen method r =–0,38, 95% Ci –0,124 and –0,584, p =0,003). Conclusion. Decease in blood plasma VEGF level or absence of its growth demonstrates aggravation of sepsis and unfavorable prognostic significance.

Acute pancreatitis, sepsis, vascular endothelial growth factor