FAMILY POLYMORPHISM OF ADRB2 GENE IN CHILDHOOD BRONCHIAL ASTHMA

Aim. To study the family polymorphism of ADRB2 gene in children with bronchial asthma, living in the city of Perm. Materials and methods. Forty four children with bronchial asthma (BA) and one of child parents underwent complex clinicolaboratory examination. Blood samples were studied on filter paper and two ADRB gene polymorphisms (Arg16Gly and Gln27Glu) were determined. Results. Occurrence rate of ADRB2 gene mutation variants among the citizens of Perm (Arg16Gly - 45,55, Gln27Glu - 27,2 %) is comparable with occurrence rate in the European population (Arg16Gly - 37-41 %, Gln27Glu - 24-30 %), but differs from the Asian population indices (Arg16Gly 73 %, Gln27Glu 52,3 %). The most frequent variant of Arg16Gly polymorphism in Perm population is the variant with mutation (GG - 45,5 %), but Gln27Glu - the variant without mutation (AA - 36,4 % and CG - 36,4 %). There is observed an association of mutation available in BA children and their mothers. Conclusions. Mutation in ADRB2 gene at Arg16Gly occurs two-fold more often and at Gln27Glu - three-fold in BA children, than in practically healthy children. In one third of BA children, Arg16Gly and Gln27Glu mutation is simultaneous, moreover, Gln27Glu is always in combination with Arg16Gly. The reason for BA exacerbation in the group of children with gene mutations is more often contact with allergen, and in children without mutation - respiratory infections. Family character of ADRB2 gene polymorphism is detected only in 27,5 % of BA children.

Arg16Gly, Gln27Glu, Bronchial asthma, β -adrenoreceptor, gene β -adrenoreceptor polymorphism, Arg16Gly, Gln27Glu