EXPERIMENTAL NSAID-INDUCED HEPATOPATHY CAUSED BY LONG USE OF NIMESULIDE

Aim. To assess the character of hepatic tissue lesion in experimental animals when modeling NSAID-hepatopathy with generally accepted histological methods. Materials and methods. Modeling of nonsteroid antiinflammatory drug-induced hepatic lesion in nonlinear white rats was performed with peroral introduction of nimesulide (Nise®) during 21 days in the following doses: 0,5 (therapeutic dose); 2,5 and 5 mg/kg. The control group was used for comparison. By the end of this experiment, histological material (hepatic tissue samples) was taken with euthanasia rules observed. Histological methods were used by standard protocols. Results. Peroral introduction of nimesulid during 21 days caused pathomorphological changes in hepatic tissue of experimental animals, typical for the toxic damage of the organ: sinusoid capillary dilatation, dystrophy and necrosis foci; at the same time, dose-dependent effect was revealed. Lymphocytic infiltrates were detected in hepatic tissue of animals perorally introduced nimesulide during 21 days; frequency of their detection increased with growth of the drug dose; the revealed changes require further study and explanation.

Nonsteroid antiinflammatory drugs, NSAID-hepatopathy, nimesulide, histopathological changes