CLINICOLABORATORY PECULIARITIES OF INFECTIOUS MONONUCLEOSIS IN PRESCHOOL CHILDREN

Aim. To study the clinical and laboratory peculiarities of infectious mononucleosis (IM) in preschool children depending on etiological factor. Materials and methods. Clinicolaboratory peculiarities of IM depending on etiological factor were analyzed in 60 patients aged 1-6 years (20 patients with Epstein-Barr virus-associated IM (EBV-IM), 20 - cytomegalovirus (CMVI) IM and 20 - mixed etiology mononucleosis (EBV+CMVI). Results. It was established that EBV-IM- caused intoxication occurred reliably more often than CMVI-IM (EBV-IM 18 patients, CMVI-IM 8 patients, p = 0,02). In case of mixed IM, splenomegalia occurred more often than in IM caused by one etiological factor (mixed IM - 18 children, EBV-IM - 13, CMVI-IM - 13, p = 0,05). In case of EBV-IM and mixed IM, all changes in blood were more marked than in CMVI-IM. Conclusions. Against the background of therapy, fiver and intoxication were the first to disappear. The most long preserved symptom was stuffiness in nose. Lymphomonocytosis, transaminasemia, atypical blood mononuclear leukocytes were more often observed in EBV-IM and mixed etiology IM. During one year after discharge from the hospital, all children more often fell ill with respiratory diseases, especially in case of CMVI-IM.

Children, infectious mononucleosis, EBV-infection, cytomegalovirus infection, herpes-virus