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Post a Comment Some pathogenetic relationships in gastroesophageal reflux disease in children
- Authors: Butorina N.V.1, Repetskaya M.N.2, Vakhrushev Y.M.1
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Affiliations:
- Izhevsk State Medical Academy
- E.A. Vagner Perm State Medical University
- Issue: Vol 41, No 4 (2024)
- Pages: 23-29
- Section: Original studies
- URL: https://journals.rcsi.science/PMJ/article/view/267867
- DOI: https://doi.org/10.17816/pmj41423-29
- ID: 267867
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Abstract
Objective. To study the relationship of the upper gastrointestinal tract acidity index and collagen metabolites and proteoglycans in children with GERD.
Materials and methods. 62 children with GERD were observed. The control group included 32 children. All children underwent esophagogastroduodenoscopy with parietal endoscopic pH-metry. The content of free hydroxyproline (FHOP), peptide-bonded hydroxyproline (PSHOP), glycosaminoglycans (GAG), as well as
a-mannosidase activity in gastric juice were studied.
Results. The hyperacidity of the pH in the esophagus, the gastric “lake” and the body of the stomach in children with GERD was revealed. A relationship between hyperacidity and the breakdown of collagen in the mucous membrane of the gastroesophageal area demonstrated by high levels of GAG, FHOP, and PSНOP
a-mannosidase in the gastric juice has been shown.
Conclusions. In children with GERD, the dynamic balance of aggressive-protective factors in the gastroduodenal area is disturbed. As a result of it, degradation of collagen in the mucous and submucous layer of the esophagus and stomach is observed.
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##article.viewOnOriginalSite##About the authors
N. V. Butorina
Izhevsk State Medical Academy
Author for correspondence.
Email: naili5@yahoo.com
PhD (Medicine), Associate Professor of the Department of Childhood Diseases and Neonatology of the Pediatric Faculty
Russian Federation, IzhevskM. N. Repetskaya
E.A. Vagner Perm State Medical University
Email: naili5@yahoo.com
DSc (Medicine), Professor, Head of the Department of Childhood Diseases of the Medical Faculty
Russian Federation, PermYa. M. Vakhrushev
Izhevsk State Medical Academy
Email: naili5@yahoo.com
DSc (Medicine), Professor, Head of the Department of Propaedeutics of Internal Diseases of the Medical Faculty
Russian Federation, IzhevskReferences
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