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Post a Comment Antitumor activity of solution of natural substance G-01 at the example of sarcoma M-1 when using adjuvant
- Authors: Mirsaeva F.Z.1, Garaishin R.M.1, Kzyrgalin S.R.1, Kitapova R.R.1, Kostromina D.A.2, Garaishina D.R.1, Zaleev T.R.1
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Affiliations:
- Bashkir State Medical University
- Republican Clinical Oncological Dispensary
- Issue: Vol 40, No 3 (2023)
- Pages: 146-151
- Section: Biology and experimental medicine
- URL: https://journals.rcsi.science/PMJ/article/view/254874
- DOI: https://doi.org/10.17816/pmj403146-151
- ID: 254874
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Abstract
Objective. To study the properties of the G-01 solution with an aluminum hydroxide-based adjuvant singly injected, while changing the concentration of the solution.
Materials and methods. The model of a transfused tumor (Sarcoma M-1) shows the antitumor activity of various concentrations of a solution of natural origin G-01 with the presence of an adjutant.
Results. The prospect of using G-01 solution in medicine as a preventive agent was established. To study the properties of a solution of G-01 with an adjuvant based on aluminum hydroxide singly injected, we found while changing the concentration of the solution that an immune response of different intensity can be induced to the same antigen, depending on the dose and multiplicity of the administered antigen.
Conclusions. In our study, which investigated the effect of G-01 solution on the body of mongrel albino white rats of the "Wistar" line in different concentrations, an optimal 15 % concentration of G-01 solution was found to have a pronounced effect on the immune system, causing the greatest antitumor activity.
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##article.viewOnOriginalSite##About the authors
F. Z. Mirsaeva
Bashkir State Medical University
Email: garaishin@list.ru
MD, PhD, Professor of the Department of Surgical Dentistry
Russian Federation, UfaRustam M. Garaishin
Bashkir State Medical University
Author for correspondence.
Email: garaishin@list.ru
ORCID iD: 0000-0001-6690-4086
Candidate of Medical Sciences, Assistant, Department of Oncology with Courses of Oncology and Pathological Anatomy
Russian Federation, UfaSh. R. Kzyrgalin
Bashkir State Medical University
Email: garaishin@list.ru
ORCID iD: 0000-0001-9721-108X
Candidate of Medical Sciences, Assistant, Department of Oncology with Courses of Oncology and Pathological Anatomy
Russian Federation, UfaR. R. Kitapova
Bashkir State Medical University
Email: garaishin@list.ru
ORCID iD: 0000-0001-9911-5665
Candidate of Pharmacological Sciences, Associate Professor, Department of Pharmacology with Course of Clinical Pharmacology
Russian Federation, UfaD. A. Kostromina
Republican Clinical Oncological Dispensary
Email: garaishin@list.ru
ORCID iD: 0000-0002-3076-850X
oncologist
Russian Federation, UfaD. R. Garaishina
Bashkir State Medical University
Email: garaishin@list.ru
ORCID iD: 0000-0002-9971-071X
fourth-year student, Pediatric Faculty
Russian Federation, UfaT. R. Zaleev
Bashkir State Medical University
Email: garaishin@list.ru
fourth-year student, Medical Faculty
Russian Federation, UfaReferences
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