Antitumor activity of solution of natural substance G-01 at the example of sarcoma M-1 without adjuvant available.

Objective. To study the properties of the solution G-01 in a single injection while changing the concentration of the solution.

Materials and methods. The monosaccharide hexose was used as a means of exposing animals. Working code: G-01. The animals were divided into 5 groups: group 1– 10 rats (who received a 10 % solution of G-01 sc, once), group 2 – 10 rats (who received a 15 % solution of G-01 sc, once), group 3 – 10 rats (who received a 20 % solution of G-01 sc, once), group 4 – 10 rats (who received a 25 % solution of G-01 sc, once), group 5 – 10 rats (control group – did not receive G-01 solutions in various concentrations).

Results. During the observation of animals, after transplanting a suspension of tumor cells, the growth of a solid tumor was detected in 100 % of cases in rats of the control group. In the experimental groups, in which 10 % and 25 % G-01 solution was used, the growth of solid tumors was also detected. Moreover, the growth rate and volume of tumors, visually, did not differ in the groups. In rats, who received a 15 % solution of G-01, a tumor developed in 3 out of 10 rats. In rats, who received a 20 % solution of G-01 – in 2 out of 10 rats.

Conclusions. The results of the work carried out prove that the substance of natural origin G-01 is a generator of adaptive immunity for the prevention of the development of the tumor process. In case of the development of the disease, it allows to achieve a tumor regression without the development of serious adverse events affecting the quality of life of animals, that is the main goal of antitumor treatment or prevention of any oncological disease.