Experience of following up couples affected by hiv and planning pregnancy with use of assisted reproductive technologies in sverdlovsk region

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Abstract

Objective. To analyze the structure of discordant (DC) and concordant (CC) pairs and outcomes of assisted reproductive technologies (ART) without taking into account the correlation of antiretroviral therapy in the Regional Center for AIDS during 2021.

Materials and methods. A retrospective analysis of medical records of 210 couples who were consulted at the State Healthcare Institution "RC AIDS" was conducted in order to obtain a conclusion from the medical commission on the possibility of carrying out the ART procedure. The following data were analyzed: channel of infection in men and women, age composition, stage of HIV infection, duration of ART use, ART outcomes.

Results. The procedures using ART are carried out in the same percentage as both DC and CC pairs. The outcomes of the ART procedure in PrEP: 2 women (6.9 %) had miscarriage,4 (13.8 %) – regression of pregnancy,23 (79.3 %) – childbirth; in CC – 1 woman (7.7 %) had miscarriage, in the remaining 12 (92.3 %) the procedure was completed with childbirth.

Conclusions. As a result of implementing the procedure with ART,35 children were born, not a single case of HIV infection in children was registered.

About the authors

Larisa A. Posokhova

Sverdlovsk Regional Center for Prevention and Control of AIDS

Email: larisadpg@gmail.com

epidemiologist

Russian Federation, 46, st. Yasnaya, 620102, Yekaterinburg

Elena A. Rosyuk

Ural State Medical University

Email: elenakdc@yandex.ru
ORCID iD: 0000-0003-1303-3955
SPIN-code: 9056-0640

Candidate of Medical Sciences, Associate Professor, Department of Obstetrics and Gynecology

Russian Federation, 3, Repina st., 620028, Yekaterinburg

Alexandra A. Shtanova

Ural State Medical University

Author for correspondence.
Email: alekshtanova@gmail.com
ORCID iD: 0000-0001-5365-7792
SPIN-code: 1086-9994

5-year student

Russian Federation, 3, Repina st., 620028, Yekaterinburg

References

  1. UNAIDS. Fact sheet; 2021, available at: https://www.unaids.org/sites/default/files/media_asset/UNAIDS_FactSheet_en.pdf.
  2. HIV infection in pregnant women: clinical recommendations of the Russian Ministry of Health. Moscow 2021 (in Russian).
  3. Medvedeva V.V., Mal'gina G.B. Reproductive issues in HIV-infected couples and the possibility of their correction with the help of assisted reproductive technology (a review). Russian Journal of Human Reproduction 2016; 22 (2): 56–64 (in Russian).
  4. Zhukova E.V., Ovodova Yu.V., Ushakova N.V., Tsareva A.S., Pronin A.Yu., Smirnov E.V., Orlova-Morozova E.A., Drobyshevskaya E.V. Experience in monitoring couples planning a pregnancy using assisted reproductive technologies in the Moscow region. Topical issues of HIV infection. Health care for children with HIV infection: Proceedings of the conference. St. Petersburg 2018; 162–164 (in Russian).
  5. Reference HIV infection in the Russian Federation as of December 31,2021, available at: https://www.who.int/ru/news-room/fact-sheets/detail/hiv-aids (in Russian).
  6. Gordon E.O., Posokhova L.A., Podymova A.S., Yastrebova E.B. Justification and development of algorithm for planned parenthood in HIV-serodiscordant couples. HIV Infection and Immunosuppressive Disorders 2019; 11 (1): 38–45 (in Russian).
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  8. Nazarenko T.A., Krasnopolskaya K.V., Gafurov Yu.T., Sundukov A.V., Isakova K.M. Effectiveness of assisted reproduction techniques to achieve pregnancy in HIV-infected patients. Infectious Diseases: News. Opinions. Education 2017; 3: 20 (in Russian).
  9. On family planning among couples affected by the problem of HIV infection, including the use of assisted reproductive technologies in the Sverdlovsk region: Order of the Ministry of Health of the Sverdlovsk Region dated June 7,2019 № 1108-p. Yekaterinburg 2019 (in Russian).
  10. On the procedure for using assisted reproductive technologies, contraindications and restrictions on their use: Order of the Ministry of Health of the Russian Federation dated July 31,2020 No. 803-n. Moscow 2020 (in Russian).
  11. HIV infection in adults: clinical recommendations of the Russian Ministry of Health. Moscow 2020 (in Russian).

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