电邮这篇文章 SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION
- 作者: Paramonova M.1, Gureeva E.1, Ozerov A.1, Snoeck R.2, Andrei G.2, Aleksandrov D.3, Khandazhinskaya A.4, Novikov M.1, Kochetkov S.4
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隶属关系:
- Volgograd State Medical University
- Rega Institute for Medical Research, KU Leuven
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Institute of Molecular Biology, Russian Academy of Sciences, V.A. Engelhardt RAS
- 期: 卷 509, 编号 1 (2023)
- 页面: 170-176
- 栏目: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135645
- DOI: https://doi.org/10.31857/S2686738922700093
- EDN: https://elibrary.ru/NAUWWD
- ID: 135645
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详细
A synthesis of a new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing in position 3 naphthalen-1-yl-, naphthalen-2-yl-, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene 9-methyl fragment was carried out. The antiviral properties of the synthesized compounds were studied against human cytomegalovirus. It was found that the compound, which has in its composition a bridge consisting of five methylene groups, has a high anti-cytomegalovirus activity in vitro.
作者简介
M. Paramonova
Volgograd State Medical University
Email: snk1952@gmail.com
Russian, Volgograd
E. Gureeva
Volgograd State Medical University
Email: snk1952@gmail.com
Russian, Volgograd
A. Ozerov
Volgograd State Medical University
Email: snk1952@gmail.com
Russian, Volgograd
R. Snoeck
Rega Institute for Medical Research, KU Leuven
Email: snk1952@gmail.com
Belgium, B-3000, Leuven, Herestraat 49 bus 1043
G. Andrei
Rega Institute for Medical Research, KU Leuven
Email: snk1952@gmail.com
Belgium, B-3000, Leuven, Herestraat 49 bus 1043
D. Aleksandrov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: snk1952@gmail.com
Russian, Moscow
A. Khandazhinskaya
Institute of Molecular Biology, Russian Academy of Sciences, V.A. Engelhardt RAS
编辑信件的主要联系方式.
Email: khandazhinskaya@bk.ru
Russian, Moscow
M. Novikov
Volgograd State Medical University
Email: snk1952@gmail.com
Russian, Volgograd
S. Kochetkov
Institute of Molecular Biology, Russian Academy of Sciences, V.A. Engelhardt RAS
编辑信件的主要联系方式.
Email: snk1952@gmail.com
Russian, Moscow
参考
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