SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

A synthesis of a new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing in position 3 naphthalen-1-yl-, naphthalen-2-yl-, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene 9-methyl fragment was carried out. The antiviral properties of the synthesized compounds were studied against human cytomegalovirus. It was found that the compound, which has in its composition a bridge consisting of five methylene groups, has a high anti-cytomegalovirus activity in vitro.

Авторлар туралы

M. Paramonova

Volgograd State Medical University

Email: snk1952@gmail.com
Russian, Volgograd

E. Gureeva

Volgograd State Medical University

Email: snk1952@gmail.com
Russian, Volgograd

A. Ozerov

Volgograd State Medical University

Email: snk1952@gmail.com
Russian, Volgograd

R. Snoeck

Rega Institute for Medical Research, KU Leuven

Email: snk1952@gmail.com
Belgium, B-3000, Leuven, Herestraat 49 bus 1043

G. Andrei

Rega Institute for Medical Research, KU Leuven

Email: snk1952@gmail.com
Belgium, B-3000, Leuven, Herestraat 49 bus 1043

D. Aleksandrov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: snk1952@gmail.com
Russian, Moscow

A. Khandazhinskaya

Institute of Molecular Biology, Russian Academy of Sciences, V.A. Engelhardt RAS

Хат алмасуға жауапты Автор.
Email: khandazhinskaya@bk.ru
Russian, Moscow

M. Novikov

Volgograd State Medical University

Email: snk1952@gmail.com
Russian, Volgograd

S. Kochetkov

Institute of Molecular Biology, Russian Academy of Sciences, V.A. Engelhardt RAS

Хат алмасуға жауапты Автор.
Email: snk1952@gmail.com
Russian, Moscow

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