SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION

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Resumo

A synthesis of a new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing in position 3 naphthalen-1-yl-, naphthalen-2-yl-, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene 9-methyl fragment was carried out. The antiviral properties of the synthesized compounds were studied against human cytomegalovirus. It was found that the compound, which has in its composition a bridge consisting of five methylene groups, has a high anti-cytomegalovirus activity in vitro.

Sobre autores

M. Paramonova

Volgograd State Medical University

Email: snk1952@gmail.com
Russian, Volgograd

E. Gureeva

Volgograd State Medical University

Email: snk1952@gmail.com
Russian, Volgograd

A. Ozerov

Volgograd State Medical University

Email: snk1952@gmail.com
Russian, Volgograd

R. Snoeck

Rega Institute for Medical Research, KU Leuven

Email: snk1952@gmail.com
Belgium, B-3000, Leuven, Herestraat 49 bus 1043

G. Andrei

Rega Institute for Medical Research, KU Leuven

Email: snk1952@gmail.com
Belgium, B-3000, Leuven, Herestraat 49 bus 1043

D. Aleksandrov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: snk1952@gmail.com
Russian, Moscow

A. Khandazhinskaya

Institute of Molecular Biology, Russian Academy of Sciences, V.A. Engelhardt RAS

Autor responsável pela correspondência
Email: khandazhinskaya@bk.ru
Russian, Moscow

M. Novikov

Volgograd State Medical University

Email: snk1952@gmail.com
Russian, Volgograd

S. Kochetkov

Institute of Molecular Biology, Russian Academy of Sciences, V.A. Engelhardt RAS

Autor responsável pela correspondência
Email: snk1952@gmail.com
Russian, Moscow

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Declaração de direitos autorais © М.П. Парамонова, Е.С. Гуреева, А.А. Озеров, R. Snoeck, G. Andrei, Д.А. Александров, А.Л. Хандажинская, М.С. Новиков, С.Н. Кочетков, 2023

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