The impact of perioperative high-protein oral nutrition supplements on postoperative outcomes in primary lung cancer: the protocol of Russian prospective, randomised, multicenter study

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Abstract

BACKGROUND: Nutritional support, including oral nutrition supplements, is an integral part of anticancer treatment, including during surgical treatment of non-small cell lung cancer. Existing evidence for the effectiveness of nutritional support in this cohort of patients is limited. We suggest that the perioperative administration of a balanced polymeric hypercaloric high-protein enteral nutritional formula by sipping as an additional nutrition can have a positive effect on the results of surgical treatment.

AIMS: 1) to assess the impact of perioperative nutritional support with high-protein oral nutrition supplements on the risk of postoperative complications, postoperative recovery of respiratory functions, nutritional status and quality of life in patients with primary lung cancer; 2) identification of possible side effects and complications when using high-protein high-energy oral nutrition supplements in patients with non-small cell lung cancer.

MATERIALS AND METHODS: Russian prospective, randomised, multicenter low-intervention study of perioperative effect of high-protein nutritional support on postoperative outcomes in the treatment of primary lung cancer with parallel groups, 1:1 randomization. The study will include 114 patients with primary non-small cell lung cancer who are scheduled for surgery. It is expected to provide nutritional support in the perioperative period for 14 days before surgery and for 14 days after it.

CONCLUSION: The present study may become one of the first evidence-based studies confirming the effectiveness of perioperative nutritional support with high-protein mixtures in patients with non-small cell lung cancer and will allow further study of the strategy of nutritional support in this category of patients.

About the authors

Larisa Ya. Volf

Nutricia LLC

Author for correspondence.
Email: volf-larisa@mail.ru
ORCID iD: 0000-0002-6025-8420
SPIN-code: 3590-9746

MD, Cand. Sci. (Med.)

Russian Federation, Riga Land Business Center, bld. 1, 26th km Baltia highway, Krasnogorsky district, 143421 Moscow region

Olga A. Obukhova

National Medical Research Center of Oncology

Email: obukhova0404@yandex.ru
ORCID iD: 0000-0003-0197-7721
SPIN-code: 6876-7701

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Nail M. Egofarov

Nutricia LLC

Email: nail.egofarov@danone.com
ORCID iD: 0000-0001-5013-0231
Russian Federation, Moscow

Mariya G. Kolesnichenko

Medical Center “Verax-Med” LLC; North-Western State Medical University

Email: maria_2182@mail.ru

MD, Cand. Sci. (Med.)

Russian Federation, Saint Petersburg; Saint Petersburg

Yurij V. Kirillov

Medical Center “Verax-Med” LLC; North-Western State Medical University

Email: Yura-1992@mail.ru
Russian Federation, Saint Petersburg; Saint Petersburg

Svetlana S. Povaga

Smolensk Regional Clinical Oncology Dispensary

Email: povaga1980@mail.ru
ORCID iD: 0000-0001-6606-606X
Russian Federation, Smolensk

Natal’ya A. Belyaeva

Clinical hospital “RZD-Medicine”

Email: n.makar1973@mail.ru
ORCID iD: 0000-0001-9616-0030
Russian Federation, Smolensk

Ekaterina V. Gordeeva

Moscow Multidisciplinary Center for Palliative Care

Email: simmetria0@mail.ru
SPIN-code: 9814-3379
Russian Federation, Moscow

Yurij V. Perminov

Saint Petersburg Research Institute of Phthisiopulmonology

Email: iuriiperminov88@gmail.com
Russian Federation, Saint Petersburg

Andrej A. Skorokhod

Saint Petersburg Research Institute of Phthisiopulmonology

Email: dr.skorokhod@mail.ru
ORCID iD: 0000-0002-1819-7206
SPIN-code: 6609-6890

MD, Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Andrej O. Nefedov

Saint Petersburg Research Institute of Phthisiopulmonology

Email: volf-larisa@mail.ru
ORCID iD: 0000-0001-6228-182X
SPIN-code: 2365-9458

MD, Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Dmitrij N. Novitsky

Clinical Oncology Dispensary

Email: dnn1978@gmail.com
Russian Federation, Omsk

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