The impact of perioperative high-protein oral nutrition supplements on postoperative outcomes in primary lung cancer: the protocol of Russian prospective, randomised, multicenter study

封面

如何引用文章

全文:

详细

BACKGROUND: Nutritional support, including oral nutrition supplements, is an integral part of anticancer treatment, including during surgical treatment of non-small cell lung cancer. Existing evidence for the effectiveness of nutritional support in this cohort of patients is limited. We suggest that the perioperative administration of a balanced polymeric hypercaloric high-protein enteral nutritional formula by sipping as an additional nutrition can have a positive effect on the results of surgical treatment.

AIMS: 1) to assess the impact of perioperative nutritional support with high-protein oral nutrition supplements on the risk of postoperative complications, postoperative recovery of respiratory functions, nutritional status and quality of life in patients with primary lung cancer; 2) identification of possible side effects and complications when using high-protein high-energy oral nutrition supplements in patients with non-small cell lung cancer.

MATERIALS AND METHODS: Russian prospective, randomised, multicenter low-intervention study of perioperative effect of high-protein nutritional support on postoperative outcomes in the treatment of primary lung cancer with parallel groups, 1:1 randomization. The study will include 114 patients with primary non-small cell lung cancer who are scheduled for surgery. It is expected to provide nutritional support in the perioperative period for 14 days before surgery and for 14 days after it.

CONCLUSION: The present study may become one of the first evidence-based studies confirming the effectiveness of perioperative nutritional support with high-protein mixtures in patients with non-small cell lung cancer and will allow further study of the strategy of nutritional support in this category of patients.

作者简介

Larisa Volf

Nutricia LLC

编辑信件的主要联系方式.
Email: volf-larisa@mail.ru
ORCID iD: 0000-0002-6025-8420
SPIN 代码: 3590-9746

MD, Cand. Sci. (Med.)

俄罗斯联邦, Riga Land Business Center, bld. 1, 26th km Baltia highway, Krasnogorsky district, 143421 Moscow region

Olga Obukhova

National Medical Research Center of Oncology

Email: obukhova0404@yandex.ru
ORCID iD: 0000-0003-0197-7721
SPIN 代码: 6876-7701

MD, Cand. Sci. (Med.)

俄罗斯联邦, Moscow

Nail Egofarov

Nutricia LLC

Email: nail.egofarov@danone.com
ORCID iD: 0000-0001-5013-0231
俄罗斯联邦, Moscow

Mariya Kolesnichenko

Medical Center “Verax-Med” LLC; North-Western State Medical University

Email: maria_2182@mail.ru

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg; Saint Petersburg

Yurij Kirillov

Medical Center “Verax-Med” LLC; North-Western State Medical University

Email: Yura-1992@mail.ru
俄罗斯联邦, Saint Petersburg; Saint Petersburg

Svetlana Povaga

Smolensk Regional Clinical Oncology Dispensary

Email: povaga1980@mail.ru
ORCID iD: 0000-0001-6606-606X
俄罗斯联邦, Smolensk

Natal’ya Belyaeva

Clinical hospital “RZD-Medicine”

Email: n.makar1973@mail.ru
ORCID iD: 0000-0001-9616-0030
俄罗斯联邦, Smolensk

Ekaterina Gordeeva

Moscow Multidisciplinary Center for Palliative Care

Email: simmetria0@mail.ru
SPIN 代码: 9814-3379
俄罗斯联邦, Moscow

Yurij Perminov

Saint Petersburg Research Institute of Phthisiopulmonology

Email: iuriiperminov88@gmail.com
俄罗斯联邦, Saint Petersburg

Andrej Skorokhod

Saint Petersburg Research Institute of Phthisiopulmonology

Email: dr.skorokhod@mail.ru
ORCID iD: 0000-0002-1819-7206
SPIN 代码: 6609-6890

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Andrej Nefedov

Saint Petersburg Research Institute of Phthisiopulmonology

Email: volf-larisa@mail.ru
ORCID iD: 0000-0001-6228-182X
SPIN 代码: 2365-9458

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Dmitrij Novitsky

Clinical Oncology Dispensary

Email: dnn1978@gmail.com
俄罗斯联邦, Omsk

参考

  1. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017;67(1):7–30. doi: 10.3322/caac.21387
  2. Laktionov KK, Artamonova EV, Borisova TN, et al. Malignant neoplasm of the bronchi and lung. Journal of Modern Oncology. 2022;24(3):269–304. (In Russ). doi: 10.26442/18151434.2022.3.201848
  3. Gyula O, András B, Zoltán B, et al. Basic principles for the prevention, diagnosis and therapy of lung cancer. Magy Onkol. 2012;56(2):114–132. (In Hungarian).
  4. Koike T, Yamato Y, Yoshiya K, Shimoyama T, Suzuki R. Intentional limited pulmonary resection for peripheral T1N0M0 small-sized lung cancer. J Thorac Cardiovasc Surg. 2003;125(4):924–928. doi: 10.1067/mtc.2003.156
  5. Yang J, Zhang Q, Wang X. Role of nutritional support for postoperative recovery of respiratory function in patients with primary lung cancer. Oncol Lett. 2018;16(5):5978–5982. doi: 10.3892/ol.2018.9348
  6. Von Haehling S, Anker SD. Prevalence, incidence and clinical impact of cachexia: facts and numbers — update 2014. J Cachexia Sarcopenia Muscle. 2014;5(4):261–263. doi: 10.1007/s13539-014-0164-8
  7. Bozzetti F. Nutrition support in patients with cancer. In: Payne-James E, Grimble G, Silk D, editors. Artificial nutrition support in clinical practice. London: Greenwich Medical Media Limited; 2001.
  8. Yang M, Shen Y, Tan L, L W. Prognostic Value of Sarcopenia in Lung Cancer: A Systematic Review and Meta-analysis. Chest. 2019;156(1):101–111. doi: 10.1016/j.chest.2019.04.115
  9. Bagan P, Berna P, de Dominicis F, et al. Nutritional status and postoperative outcome after pneumonectomy for lung cancer. Ann Thorac Surg. 2013;95(2):392–396. doi: 10.1016/j.athoracsur.2012.06.023
  10. Antoun S, Rey A, Beal J, et al. Nutritional risk factors in planned oncologic surgery: what clinical and biological parameters should be routinely used? World J Surg. 2009;33(8):1633–1640. doi: 10.1007/s00268-009-0033-3
  11. Gupta D, Lis CG. Pretreatment serum albumin as a predictor of cancer survival: a systematic review of the epidemiological literature. Nutr J. 2010;9:69. doi: 10.1186/1475-2891-9-69
  12. Simons JP, Schols AM, Buurman WA, Wouters EF. Weight loss and low body cell mass in males with lung cancer: relationship with systemic inflammation, acute-phase response, resting energy expenditure, and catabolic and anabolic hormones. Clin Sci. 1999;97(2):215–223.
  13. Stoelben E, Huber RM, Müller RP, Wolf J. Multimodality therapy for lung cancer. Internist (Berl). 2010;51(11):1348–1357. doi: 10.1007/s00108-010-2674-6
  14. Huhmann MB, August DA. Review of American Society for Parenteral and Enteral Nutrition (ASPEN) clinical guidelines for nutrition support in cancer patients: nutrition screening and assessment. Nutr Clin Pract. 2008;23(2):182–188. doi: 10.1177/0884533608314530
  15. Ivanova AS, Obukhova OA, Kurmukov IA, Volf LYa. Review of ESPEN-2021 Practice Guidelines for Patients with Cancer. Part 2: Interventions Relevant to Specific Patient Categories. Clinical nutrition and metabolism. 2022;3(4):193–206. (In Russ). doi: https://doi.org/10.17816/clinutr119059
  16. Escortell SR, Reig GM. Enteral nutrition on the nurtritional status of cancer. Nutr Hosp. 2015;32(4):1408–1416. doi: 10.3305/nh.2015.32.4.9227
  17. Kruizenga HM, Schager M, van Dronkelaar C, Naumann E. Protein intake during hospital admission; Dutch national data on protein intake in 339,720 malnourished patients from 2009–2019. Clin Nutr Open Science. 2022;41:74–81. doi: 10.1016/j.nutos.2021.12.001
  18. O’Sullivan E, McAdam A, O’Sullivan M, et al. Nutritional status of pre-operative early stage lung cancer patients and dietary intake assessment post-operatively. Clin Nutr ESPEN. 2017;22:138.
  19. Ravasco P, Monteiro Grillo I, Marques Vidal P, Camilo M. Nutritional counselling vs supplements: A prospective randomised controlled trial in head-neck cancer patients undergoing radiotherapy. Clin Nutr. 2003;22:S63–S64. doi: 10.1016/s0261-5614(03)80236-4
  20. Turcott JG, Barragán PA, Zatarain ZL, Arrieta O. Dysgeusia in Non-Small Cell Lung Cancer Patients with Anorexia. Clin Nutr. 2019; 38:S96–S97. doi: 10.1016/S0261-5614(19)32735-9
  21. De Haan J, Renken RJ, Moshage Y, et al. Self-reported taste and smell alterations and the liking of oral nutritional supplements with sensory-adapted flavors in cancer patients receiving systemic antitumor treatment. Support Care Cancer. 2021;29(10):5691–5699. doi: 10.1007/s00520-021-06049-4
  22. Obukhova OA, Kurmukov IA, Ryk AA. The effect of nutritional support on nutritional status, quality of life, and survival in cancer patients receiving systemic anticancer therapy. Clinical nutrition and metabolism. 2022;3(1):50–61. (In Russ). doi: https://doi.org/10.17816/clinutr104771
  23. Goeckenjan G, Sitter H, Thomas M, et al. Prevention, diagnosis, therapy, and follow-up of lung cancer. Pneumologie. 2010;64:1–164. Suppl. 2. P. e1-164. (In German). doi: 10.1055/s-0029-1243837
  24. Kaya SO, Akcam TI, Ceylan KC. Is preoperative protein-rich nutrition effective on postoperative outcome in non-small cell lung cancer surgery? A prospective randomized study. J Cardiothorac Surg. 2016;11:14. doi: 10.1186/s13019-016-0407-1
  25. Smedley F, Bowling T, James M, et al. Randomized clinical trial of the effects of preoperative and postoperative oral nutritional supplements on clinical course and cost of care. Br J Surg. 2004; 91(8):983–990. doi: 10.1002/bjs.4578
  26. Mudunov АМ, Udintsov DB. Nutritional support of patients after surgical treatment for oral squamous cell carcinoma. Head and Neck Tumors. 2017;7(3);47–52. (In Russ). doi: 10.17650/2222-1468-2017-7-3-47-52
  27. Khrykov GN, Strukov EYu, Khalikov АD. Nutritional support aspects with fast track programme in planned surgeries for colon cancer in elderly patients. Messenger of Anesthesiology and Resuscitation. 2016;13(5):30–36. doi: 10.21292/2078-5658-2016-13-5-30-36
  28. Sánchez-Lara K, Turcott JG, Juárez-Hernández E, et al. Effects of an oral nutritional supplement containing eicosapentaenoic acid on nutritional and clinical outcomes in patients with advanced non-small cell lung cancer: Randomised trial. Clin Nutr, 2014;33(6):1017–1023. doi: 10.1016/j.clnu.2014.03.006
  29. Gordeeva OS. Optimizatsiya perioperatsionnoi nutritivnoi podderzhki u bol’nykh rakom legkogo [dissertation]. Moscow; 2011. (In Russ). 165 p.
  30. Tsiryateva SB, Sativaldaev MN, Abgaryan AS, Pilenko SA. Clinical and pharmacoeconomical efficacy of preoperative nutrition support in early rehabilitation of patients with lung cancer. Meditsinskaya nauka i obrazovanie Urala. 2019;20(3(99));154–157. (In Russ).
  31. Kondrup J, Rasmussen HH, Hamberg O, et al. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr. 2003;22(3):321–336. doi: 10.1016/s0261-5614(02)00214-5
  32. Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5(6):649–655.
  33. Park S, Ahn HJ, Yang M, et al. The prognostic nutritional index and postoperative complications after curative lung cancer resection: A retrospective cohort study. J Thorac Cardiovasc Surg. 2020;160(1):276–285.e1. doi: 10.1016/j.jtcvs.2019.10.105
  34. Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365–376. doi: 10.1093/jnci/85.5.365
  35. Fietkau R, Lewitzki V, Kuhnt T, et al. A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: results of a randomized, controlled, multicenter trial. Cancer. 2013;119(18):3343–3353. doi: 10.1002/cncr.28197
  36. Caccialanza R, Goldwasser F, Marschal O, et al. Unmet needs in clinical nutrition in oncology: a multinational analysis of real-world evidence. Ther Adv Med Oncol. 2020;12:1758835919899852. doi: 10.1177/1758835919899852
  37. Caccialanza R, de Lorenzo F, Gianotti L, et al. Nutritional support for cancer patients: still a neglected right? Support Care Cancer. 2017;25(10):3001–3004. doi: 10.1007/s00520-017-3826-1
  38. Landgrebe M, Tobberup R, Carus A, Rasmussen HH. GLIM diagnosed malnutrition predicts clinical outcomes and quality of life in patients with non-small cell lung cancer. Clin Nutr. 2023;42(2): 190–198. doi: 10.1016/j.clnu.2022.12.011
  39. Aotani N, Yasui-Yamada S, Kagiya N, et al. Malnutrition by European Society for Clinical Nutrition and Metabolism criteria predicts prognosis in patients with gastrointestinal and hepatobiliary–pancreatic cancer. Clin Nutr ESPEN. 2021;42:265–271. doi: 10.1016/j.clnesp.2021.01.023
  40. Yu K, Zheng X, Wang G, Liu M, Li Y, Yu P, et al. Immunonutrition vs standard nutrition for Cancer patients: a systematic review and Meta-analysis (part 1). JPEN J Parenter Enteral Nutr. 2020;44(5): 742–767. doi: 10.1002/jpen.1736
  41. Buzquurz F, Bojesen RD, Grube C, Madsen MT, Gögenur I. Impact of oral preoperative and perioperative immunonutrition on postoperative infection and mortality in patients undergoing cancer surgery: systematic review and meta-analysis with trial sequential analysis. BJS Open. 2020;4(5):764–775. doi: 10.1002/bjs5.50314
  42. Hébuterne X, Lemarié E, Michallet M, de Montreuil CB, Schneider SM, Goldwasser F. Prevalence of malnutrition and current use of nutrition support in patients with cancer. JPEN J Parenter Enteral Nutr. 2014 Feb;38(2):196–204. doi: 10.1177/0148607113502674
  43. Aahlin EK, Tranø G, Johns N, et al. Risk factors, complications and survival after upper abdominal surgery: a prospective cohort study. BMC Surg. 2015;15:83. doi: 10.1186/s12893-015-0069-2

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Eco-Vector, 2023

Creative Commons License
此作品已接受知识共享署名-非商业性使用-禁止演绎 4.0国际许可协议的许可。

##common.cookie##