The role of circadian rhythms and the “cellular clock” in age-associated diseases


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Abstract

Circadian oscillations are characteristic of almost all processes in living organisms. Disturbances in circadian rhythms may constitute either a cause or a consequence of different diseases. The article analyzes literature data on the role of changes in the circadian rhythms and the expression of clock genes in the development of neurodegenerative and cardiovascular diseases, metabolic syndrome, and type 2 diabetes mellitus in human beings and animals.

About the authors

A. V. Panchenko

Petrov Research Institute of Oncology; Almazov Northwestern Federal Medical Research Center

Author for correspondence.
Email: ando_pan@mail.ru
Russian Federation, pos. Pesochnyi, St. Petersburg, 197758; St. Petersburg, 197341

E. A. Gubareva

Petrov Research Institute of Oncology

Email: ando_pan@mail.ru
Russian Federation, pos. Pesochnyi, St. Petersburg, 197758

V. N. Anisimov

Petrov Research Institute of Oncology

Email: ando_pan@mail.ru
Russian Federation, pos. Pesochnyi, St. Petersburg, 197758

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