Cardioprotective effect of a new glutamic acid derivative, glufimet, under conditions of acute immobilization and painful stress in animals of different ages

Abstract

The effect of 24-hour immobilization and painful stress on myocardial contractility was studied in young (6-month), middle-aged (12-month) and old (24-month) female rats. A reduction of the functional heart reserves was revealed. This manifested itself in a lower growth of the myocardial contraction and relaxation rates (+dP/dt max and–dP/dt max), the left ventricular pressure (LVP), the maximum intensity of the functioning of the structures (MIFS) under conditions of increased pre- and afterload, and stimulation of the cardiac adrenergic receptors, which was especially pronounced in the group of 24-month-old rats. During the load tests, higher growth indicators of +dP/dt max,–dP/dt max, LVP, and MIFS were observed in animals of all age groups treated with glufimet at a dose of 29 mg/kg before and after stress; these indicators were most significant in older rats compared to young and middle-aged animals. A reference drug, Phenibut, improves the studied parameters equally in 6-, 12-, and 24-month-old females subjected to stress.