Cardioprotective effect of a new glutamic acid derivative, glufimet, under conditions of acute immobilization and painful stress in animals of different ages
- Autores: Perfilova V.1, Sadikova N.1, Prokofiev I.1, Inozemtsev O.1, Tyurenkov I.1
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Afiliações:
- Volgograd State Medical University
- Edição: Volume 6, Nº 3 (2016)
- Páginas: 231-237
- Seção: Article
- URL: https://journals.rcsi.science/2079-0570/article/view/205458
- DOI: https://doi.org/10.1134/S2079057016030073
- ID: 205458
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Resumo
The effect of 24-hour immobilization and painful stress on myocardial contractility was studied in young (6-month), middle-aged (12-month) and old (24-month) female rats. A reduction of the functional heart reserves was revealed. This manifested itself in a lower growth of the myocardial contraction and relaxation rates (+dP/dt max and–dP/dt max), the left ventricular pressure (LVP), the maximum intensity of the functioning of the structures (MIFS) under conditions of increased pre- and afterload, and stimulation of the cardiac adrenergic receptors, which was especially pronounced in the group of 24-month-old rats. During the load tests, higher growth indicators of +dP/dt max,–dP/dt max, LVP, and MIFS were observed in animals of all age groups treated with glufimet at a dose of 29 mg/kg before and after stress; these indicators were most significant in older rats compared to young and middle-aged animals. A reference drug, Phenibut, improves the studied parameters equally in 6-, 12-, and 24-month-old females subjected to stress.
Sobre autores
V. Perfilova
Volgograd State Medical University
Autor responsável pela correspondência
Email: vnperfilova@gmail.com
Rússia, pl. Pavshikh Bortsov 1, Volgograd, 400131
N. Sadikova
Volgograd State Medical University
Email: vnperfilova@gmail.com
Rússia, pl. Pavshikh Bortsov 1, Volgograd, 400131
I. Prokofiev
Volgograd State Medical University
Email: vnperfilova@gmail.com
Rússia, pl. Pavshikh Bortsov 1, Volgograd, 400131
O. Inozemtsev
Volgograd State Medical University
Email: vnperfilova@gmail.com
Rússia, pl. Pavshikh Bortsov 1, Volgograd, 400131
I. Tyurenkov
Volgograd State Medical University
Email: vnperfilova@gmail.com
Rússia, pl. Pavshikh Bortsov 1, Volgograd, 400131