Email this article The Cytotoxic Effect of Activated Recombinant Anti-Mullerian Hormone As a Basis for the Development of a New Drug
- Authors: Rak A.Y.1,2, Trofimov A.V.1, Pigareva N.V.1, Simbirtsev A.S.1, Ischenko A.M.1
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Affiliations:
- State Research Institute of Highly Pure Biopreparations
- St. Petersburg State University
- Issue: Vol 12, No 6 (2018)
- Pages: 460-467
- Section: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212793
- DOI: https://doi.org/10.1134/S1990519X18060093
- ID: 212793
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Abstract
In the present study, the antitumor activity of activated recombinant human anti-Mullerian hormone (rAMH) against the NBL-7 and OVCAR3 cell lines was investigated. It was shown that the hormone contained in highly purified preparations not only has the ability to bind to the recombinant type II receptor (MISRII), but also possesses a cytotoxic effect against cells expressing MISRII. The obtained data may underlie the basis for the development of the first domestic anticancer drug based on activated rAMH.
About the authors
A. Ya. Rak
State Research Institute of Highly Pure Biopreparations; St. Petersburg State University
Author for correspondence.
Email: rak@hpb-spb.com
Russian Federation, St. Petersburg, 197110; St. Petersburg, 199034
A. V. Trofimov
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Russian Federation, St. Petersburg, 197110
N. V. Pigareva
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Russian Federation, St. Petersburg, 197110
A. S. Simbirtsev
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Russian Federation, St. Petersburg, 197110
A. M. Ischenko
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Russian Federation, St. Petersburg, 197110
