The Cytotoxic Effect of Activated Recombinant Anti-Mullerian Hormone As a Basis for the Development of a New Drug
- Авторы: Rak A.Y.1,2, Trofimov A.V.1, Pigareva N.V.1, Simbirtsev A.S.1, Ischenko A.M.1
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Учреждения:
- State Research Institute of Highly Pure Biopreparations
- St. Petersburg State University
- Выпуск: Том 12, № 6 (2018)
- Страницы: 460-467
- Раздел: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212793
- DOI: https://doi.org/10.1134/S1990519X18060093
- ID: 212793
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Аннотация
In the present study, the antitumor activity of activated recombinant human anti-Mullerian hormone (rAMH) against the NBL-7 and OVCAR3 cell lines was investigated. It was shown that the hormone contained in highly purified preparations not only has the ability to bind to the recombinant type II receptor (MISRII), but also possesses a cytotoxic effect against cells expressing MISRII. The obtained data may underlie the basis for the development of the first domestic anticancer drug based on activated rAMH.
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Об авторах
A. Rak
State Research Institute of Highly Pure Biopreparations; St. Petersburg State University
Автор, ответственный за переписку.
Email: rak@hpb-spb.com
Россия, St. Petersburg, 197110; St. Petersburg, 199034
A. Trofimov
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Россия, St. Petersburg, 197110
N. Pigareva
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Россия, St. Petersburg, 197110
A. Simbirtsev
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Россия, St. Petersburg, 197110
A. Ischenko
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Россия, St. Petersburg, 197110
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