The Cytotoxic Effect of Activated Recombinant Anti-Mullerian Hormone As a Basis for the Development of a New Drug
- 作者: Rak A.1,2, Trofimov A.1, Pigareva N.1, Simbirtsev A.1, Ischenko A.1
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隶属关系:
- State Research Institute of Highly Pure Biopreparations
- St. Petersburg State University
- 期: 卷 12, 编号 6 (2018)
- 页面: 460-467
- 栏目: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212793
- DOI: https://doi.org/10.1134/S1990519X18060093
- ID: 212793
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详细
In the present study, the antitumor activity of activated recombinant human anti-Mullerian hormone (rAMH) against the NBL-7 and OVCAR3 cell lines was investigated. It was shown that the hormone contained in highly purified preparations not only has the ability to bind to the recombinant type II receptor (MISRII), but also possesses a cytotoxic effect against cells expressing MISRII. The obtained data may underlie the basis for the development of the first domestic anticancer drug based on activated rAMH.
作者简介
A. Rak
State Research Institute of Highly Pure Biopreparations; St. Petersburg State University
编辑信件的主要联系方式.
Email: rak@hpb-spb.com
俄罗斯联邦, St. Petersburg, 197110; St. Petersburg, 199034
A. Trofimov
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
俄罗斯联邦, St. Petersburg, 197110
N. Pigareva
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
俄罗斯联邦, St. Petersburg, 197110
A. Simbirtsev
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
俄罗斯联邦, St. Petersburg, 197110
A. Ischenko
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
俄罗斯联邦, St. Petersburg, 197110