The Cytotoxic Effect of Activated Recombinant Anti-Mullerian Hormone As a Basis for the Development of a New Drug
- Авторлар: Rak A.1,2, Trofimov A.1, Pigareva N.1, Simbirtsev A.1, Ischenko A.1
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Мекемелер:
- State Research Institute of Highly Pure Biopreparations
- St. Petersburg State University
- Шығарылым: Том 12, № 6 (2018)
- Беттер: 460-467
- Бөлім: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212793
- DOI: https://doi.org/10.1134/S1990519X18060093
- ID: 212793
Дәйексөз келтіру
Аннотация
In the present study, the antitumor activity of activated recombinant human anti-Mullerian hormone (rAMH) against the NBL-7 and OVCAR3 cell lines was investigated. It was shown that the hormone contained in highly purified preparations not only has the ability to bind to the recombinant type II receptor (MISRII), but also possesses a cytotoxic effect against cells expressing MISRII. The obtained data may underlie the basis for the development of the first domestic anticancer drug based on activated rAMH.
Негізгі сөздер
Авторлар туралы
A. Rak
State Research Institute of Highly Pure Biopreparations; St. Petersburg State University
Хат алмасуға жауапты Автор.
Email: rak@hpb-spb.com
Ресей, St. Petersburg, 197110; St. Petersburg, 199034
A. Trofimov
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Ресей, St. Petersburg, 197110
N. Pigareva
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Ресей, St. Petersburg, 197110
A. Simbirtsev
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Ресей, St. Petersburg, 197110
A. Ischenko
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Ресей, St. Petersburg, 197110