The Cytotoxic Effect of Activated Recombinant Anti-Mullerian Hormone As a Basis for the Development of a New Drug
- Autores: Rak A.1,2, Trofimov A.1, Pigareva N.1, Simbirtsev A.1, Ischenko A.1
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Afiliações:
- State Research Institute of Highly Pure Biopreparations
- St. Petersburg State University
- Edição: Volume 12, Nº 6 (2018)
- Páginas: 460-467
- Seção: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212793
- DOI: https://doi.org/10.1134/S1990519X18060093
- ID: 212793
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Resumo
In the present study, the antitumor activity of activated recombinant human anti-Mullerian hormone (rAMH) against the NBL-7 and OVCAR3 cell lines was investigated. It was shown that the hormone contained in highly purified preparations not only has the ability to bind to the recombinant type II receptor (MISRII), but also possesses a cytotoxic effect against cells expressing MISRII. The obtained data may underlie the basis for the development of the first domestic anticancer drug based on activated rAMH.
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Sobre autores
A. Rak
State Research Institute of Highly Pure Biopreparations; St. Petersburg State University
Autor responsável pela correspondência
Email: rak@hpb-spb.com
Rússia, St. Petersburg, 197110; St. Petersburg, 199034
A. Trofimov
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Rússia, St. Petersburg, 197110
N. Pigareva
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Rússia, St. Petersburg, 197110
A. Simbirtsev
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Rússia, St. Petersburg, 197110
A. Ischenko
State Research Institute of Highly Pure Biopreparations
Email: rak@hpb-spb.com
Rússia, St. Petersburg, 197110