Justification. Information on objective data and reference indicators characterizing the state and relationship of the maxillofacial organs with the General adaptive syndrome and stress is poorly understood. The purpose of research: experimental and clinical justification of the method of complex and rapid diagnosis of stress as a manifestation of AOS in students on metabolic, morphometric and functional parameters of tissues of the maxillofacial region. Materials and methods. The study involved 30 students aged 18 to 21 years (17 females and 13 males) in the period before and after training sessions with mental stress, after physical exertion, as well as after the end of the first year of study, at the beginning and in the middle of the first semester of the second year of study. The following tests were performed: electrodontodiagnosis, pH-metry and fluorescence diagnostics of saliva, thermometry of periodontal tissues, Rod test, calculation of the Sheikh-Zade formula, spielberger psychological test. Statistical analysis of the results was carried out using standard statistical complexes in Microsoft Excel. Results. EDI: after two sessions with mental stress - an increase of 46.5% (p<0.01). After physical unloading - recovery by 23.2% (p<0.05). pH-metry of saliva: at the end of the school year of 6.41 ± 0,19, after two months of summer vacation - of 6.87± 0,11, and in the middle of the first semester of the second year - of 6.63 ± 0,11. Comparative analysis of thermometry parameters of periodontal tissues in students at the end of the school year and after two months of rest - an increase in gum temperature, on average, by 0.62 °C (p<0.05). When measuring the fluorescence intensity of saliva samples before and after the training load in comparison with the initial state, it was revealed a significant increase in the wavelength range of 600-650 nm and an increase in the integral intensity of 10-30 times, and after a night rest - a decrease of 7-10 times. Test bar: after two sessions with mental stress - deterioration by 31.5% (p<0.001), after physical unloading - improvement by 19.3% (p<0.001). Formula Sheikh Zade: after two sessions with mental stress-an increase of 57.2% (p<0.001), after physical unloading - the dynamics of a decrease of 18.6% (p<0.05). Psychological test of spielberger after summer vacation: prevalence of average level of personal anxiety and high level of reactive anxiety. Conclusion: these methods of examination can be reasonably included in the method of complex diagnosis of CCA and its correction in a wide range of students at all stages of the educational process. The presented indicators of the maxillofacial area objectively and multifactorially reflect the dental status of the CHLO and can be used as a reference in the assessment of stress loads in students at the stages of their training.