Отправить статью по E-mail The New Plant Expression System for the Development of Vaccines against Papillomaviruses
- Авторы: Salyaev R.K.1, Rekoslavskaya N.I.1,2, Stolbikov A.S.1
-
Учреждения:
- Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences
- Irkutsk Scientific Center, Siberian Branch, Russian Academy of Sciences
- Выпуск: Том 484, № 1 (2019)
- Страницы: 52-54
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212743
- DOI: https://doi.org/10.1134/S1607672919010150
- ID: 212743
Цитировать
Открытый доступ
Доступ предоставлен
Только для подписчиков
Аннотация
To enhance the synthesis of antigenic envelope proteins L1 of high-grade papillomavirus types HPV16, HPV18, HPV31, and HPV45, the sequence of the gene encoding the cucumber mosaic virus replicase (RdRP CMV) was inserted into the genetic construct. This made it possible to increase the production of these antigenic proteins to 25–27 μg/mg total soluble protein.
Об авторах
R. Salyaev
Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: salyaev@sifibr.irk.ru
Россия, Irkutsk, 664033
N. Rekoslavskaya
Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences; Irkutsk Scientific Center, Siberian Branch,Russian Academy of Sciences
Автор, ответственный за переписку.
Email: rekoslavskaya@sifibr.irk.ru
Россия, Irkutsk, 664033; Irkutsk, 664033
A. Stolbikov
Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences
Email: rekoslavskaya@sifibr.irk.ru
Россия, Irkutsk, 664033
Дополнительные файлы
