The New Plant Expression System for the Development of Vaccines against Papillomaviruses


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Resumo

To enhance the synthesis of antigenic envelope proteins L1 of high-grade papillomavirus types HPV16, HPV18, HPV31, and HPV45, the sequence of the gene encoding the cucumber mosaic virus replicase (RdRP CMV) was inserted into the genetic construct. This made it possible to increase the production of these antigenic proteins to 25–27 μg/mg total soluble protein.

Sobre autores

R. Salyaev

Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences

Autor responsável pela correspondência
Email: salyaev@sifibr.irk.ru
Rússia, Irkutsk, 664033

N. Rekoslavskaya

Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences; Irkutsk Scientific Center, Siberian Branch,
Russian Academy of Sciences

Autor responsável pela correspondência
Email: rekoslavskaya@sifibr.irk.ru
Rússia, Irkutsk, 664033; Irkutsk, 664033

A. Stolbikov

Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences

Email: rekoslavskaya@sifibr.irk.ru
Rússia, Irkutsk, 664033

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