The New Plant Expression System for the Development of Vaccines against Papillomaviruses


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To enhance the synthesis of antigenic envelope proteins L1 of high-grade papillomavirus types HPV16, HPV18, HPV31, and HPV45, the sequence of the gene encoding the cucumber mosaic virus replicase (RdRP CMV) was inserted into the genetic construct. This made it possible to increase the production of these antigenic proteins to 25–27 μg/mg total soluble protein.

作者简介

R. Salyaev

Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences

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Email: salyaev@sifibr.irk.ru
俄罗斯联邦, Irkutsk, 664033

N. Rekoslavskaya

Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences; Irkutsk Scientific Center, Siberian Branch,
Russian Academy of Sciences

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Email: rekoslavskaya@sifibr.irk.ru
俄罗斯联邦, Irkutsk, 664033; Irkutsk, 664033

A. Stolbikov

Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences

Email: rekoslavskaya@sifibr.irk.ru
俄罗斯联邦, Irkutsk, 664033

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