Enviar artigo por via de e-mail Synuclein Deficiency Decreases the Efficiency of Dopamine Uptake by Synaptic Vesicles
- Autores: Ninkina N.N.1,2, Tarasova T.V.1,2, Chaprov K.D.1, Goloborshcheva V.V.1, Bachurin S.O.1, Buchman V.L.1,2
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Afiliações:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Cardiff University, School of Biosciences, Sir Martin Evans Building, Museum Avenue
- Edição: Volume 486, Nº 1 (2019)
- Páginas: 168-170
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212988
- DOI: https://doi.org/10.1134/S1607672919030025
- ID: 212988
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Resumo
In the present study, we analyzed the uptake of radiolabeled dopamine by intact synaptosomes and purified synaptic vesicles isolated from the dorsal striatum of mice with constitutive inactivation of all three synuclein-coding genes and wild-type mice. Synuclein deficiency substantially compromised the uptake of this neurotransmitter by synaptic vesicles but had no effect on synaptosomal dopamine uptake.
Sobre autores
N. Ninkina
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
Rússia, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
T. Tarasova
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
Rússia, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
K. Chaprov
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Autor responsável pela correspondência
Email: chapkir@gmail.com
Rússia, Chernogolovka,
Moscow oblast, 142432
V. Goloborshcheva
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: chapkir@gmail.com
Rússia, Chernogolovka,
Moscow oblast, 142432
S. Bachurin
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: chapkir@gmail.com
Rússia, Chernogolovka,
Moscow oblast, 142432
V. Buchman
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
Rússia, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
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