Synuclein Deficiency Decreases the Efficiency of Dopamine Uptake by Synaptic Vesicles


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Аннотация

In the present study, we analyzed the uptake of radiolabeled dopamine by intact synaptosomes and purified synaptic vesicles isolated from the dorsal striatum of mice with constitutive inactivation of all three synuclein-coding genes and wild-type mice. Synuclein deficiency substantially compromised the uptake of this neurotransmitter by synaptic vesicles but had no effect on synaptosomal dopamine uptake.

Авторлар туралы

N. Ninkina

Institute of Physiologically Active Compounds,
Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue

Email: chapkir@gmail.com
Ресей, Chernogolovka, Moscow oblast, 142432; Cardiff, CF10 3AX

T. Tarasova

Institute of Physiologically Active Compounds,
Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue

Email: chapkir@gmail.com
Ресей, Chernogolovka, Moscow oblast, 142432; Cardiff, CF10 3AX

K. Chaprov

Institute of Physiologically Active Compounds,
Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: chapkir@gmail.com
Ресей, Chernogolovka, Moscow oblast, 142432

V. Goloborshcheva

Institute of Physiologically Active Compounds,
Russian Academy of Sciences

Email: chapkir@gmail.com
Ресей, Chernogolovka, Moscow oblast, 142432

S. Bachurin

Institute of Physiologically Active Compounds,
Russian Academy of Sciences

Email: chapkir@gmail.com
Ресей, Chernogolovka, Moscow oblast, 142432

V. Buchman

Institute of Physiologically Active Compounds,
Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue

Email: chapkir@gmail.com
Ресей, Chernogolovka, Moscow oblast, 142432; Cardiff, CF10 3AX

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