Мақаланы E-mail арқылы жіберу Synuclein Deficiency Decreases the Efficiency of Dopamine Uptake by Synaptic Vesicles
- Авторлар: Ninkina N.N.1,2, Tarasova T.V.1,2, Chaprov K.D.1, Goloborshcheva V.V.1, Bachurin S.O.1, Buchman V.L.1,2
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Мекемелер:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Cardiff University, School of Biosciences, Sir Martin Evans Building, Museum Avenue
- Шығарылым: Том 486, № 1 (2019)
- Беттер: 168-170
- Бөлім: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212988
- DOI: https://doi.org/10.1134/S1607672919030025
- ID: 212988
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
In the present study, we analyzed the uptake of radiolabeled dopamine by intact synaptosomes and purified synaptic vesicles isolated from the dorsal striatum of mice with constitutive inactivation of all three synuclein-coding genes and wild-type mice. Synuclein deficiency substantially compromised the uptake of this neurotransmitter by synaptic vesicles but had no effect on synaptosomal dopamine uptake.
Авторлар туралы
N. Ninkina
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
Ресей, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
T. Tarasova
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
Ресей, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
K. Chaprov
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: chapkir@gmail.com
Ресей, Chernogolovka,
Moscow oblast, 142432
V. Goloborshcheva
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: chapkir@gmail.com
Ресей, Chernogolovka,
Moscow oblast, 142432
S. Bachurin
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: chapkir@gmail.com
Ресей, Chernogolovka,
Moscow oblast, 142432
V. Buchman
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
Ресей, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
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