Synuclein Deficiency Decreases the Efficiency of Dopamine Uptake by Synaptic Vesicles
- Авторы: Ninkina N.N.1,2, Tarasova T.V.1,2, Chaprov K.D.1, Goloborshcheva V.V.1, Bachurin S.O.1, Buchman V.L.1,2
-
Учреждения:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Cardiff University, School of Biosciences, Sir Martin Evans Building, Museum Avenue
- Выпуск: Том 486, № 1 (2019)
- Страницы: 168-170
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212988
- DOI: https://doi.org/10.1134/S1607672919030025
- ID: 212988
Цитировать
Аннотация
In the present study, we analyzed the uptake of radiolabeled dopamine by intact synaptosomes and purified synaptic vesicles isolated from the dorsal striatum of mice with constitutive inactivation of all three synuclein-coding genes and wild-type mice. Synuclein deficiency substantially compromised the uptake of this neurotransmitter by synaptic vesicles but had no effect on synaptosomal dopamine uptake.
Об авторах
N. Ninkina
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
Россия, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
T. Tarasova
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
Россия, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
K. Chaprov
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Автор, ответственный за переписку.
Email: chapkir@gmail.com
Россия, Chernogolovka,
Moscow oblast, 142432
V. Goloborshcheva
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: chapkir@gmail.com
Россия, Chernogolovka,
Moscow oblast, 142432
S. Bachurin
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: chapkir@gmail.com
Россия, Chernogolovka,
Moscow oblast, 142432
V. Buchman
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
Россия, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
Дополнительные файлы
